Genomic landscape of lymphatic malformations: a case series and response to the PI3Kα inhibitor alpelisib in an N-of-1 clinical trial

BACKGROUND: Lymphatic malformations (LMs) often pose treatment challenges due to a large size or a critical location that could lead to disfigurement, and there are no standardized treatment approaches for either refractory or unresectable cases. METHODS: We examined the genomic landscape of a patie...

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Detalles Bibliográficos
Autores principales: Shaheen, Montaser F, Tse, Julie Y, Sokol, Ethan S, Masterson, Margaret, Bansal, Pranshu, Rabinowitz, Ian, Tarleton, Christy A, Dobroff, Andrey S, Smith, Tracey L, Bocklage, Thèrése J, Mannakee, Brian K, Gutenkunst, Ryan N, Bischoff, Joyce, Ness, Scott A, Riedlinger, Gregory M, Groisberg, Roman, Pasqualini, Renata, Ganesan, Shridar, Arap, Wadih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255965/
https://www.ncbi.nlm.nih.gov/pubmed/35787784
http://dx.doi.org/10.7554/eLife.74510

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