Coupling of acceptor-substituted diazo compounds and tertiary thioamides: synthesis of enamino carbonyl compounds and their pharmacological evaluation

This paper describes the synthesis of enamino carbonyl compounds by the copper(i)-catalyzed coupling of acceptor-substituted diazo compounds and tertiary thioamides. We plan to use this method to synthesize indolizidine (−)-237D analogs to find α6-selective antismoking agents. Therefore, we also per...

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Detalles Bibliográficos
Autores principales: Secka, Jim, Pal, Arpan, Acquah, Francis A., Mooers, Blaine H. M., Karki, Anand B., Mahjoub, Dania, Fakhr, Mohamed K., Wallace, David R., Okada, Takuya, Toyooka, Naoki, Kuta, Adama, Koduri, Naga, Herndon, Deacon, Roberts, Kenneth P., Wang, Zhiguo, Hileman, Bethany, Rajagopal, Nisha, Hussaini, Syed R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256013/
https://www.ncbi.nlm.nih.gov/pubmed/35865562
http://dx.doi.org/10.1039/d2ra02415b

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