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The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer

OBJECTIVE: To investigate the relationship between vascular endothelial growth factor-C (VEGF-C) and tumor-associated macrophages in oral cancer (TAMs) with lymph node metastasis. METHOD: From January 2018 to January 2022, 155 cases of oral cancer tissues and 165 cases of normal mucosal tissues were...

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Autores principales: Yuan, Wei, Tan, Tao, Liu, Ying, Du, Yingjie, Zhang, Shengjuan, Wang, Junrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256394/
https://www.ncbi.nlm.nih.gov/pubmed/35800004
http://dx.doi.org/10.1155/2022/9910049
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author Yuan, Wei
Tan, Tao
Liu, Ying
Du, Yingjie
Zhang, Shengjuan
Wang, Junrong
author_facet Yuan, Wei
Tan, Tao
Liu, Ying
Du, Yingjie
Zhang, Shengjuan
Wang, Junrong
author_sort Yuan, Wei
collection PubMed
description OBJECTIVE: To investigate the relationship between vascular endothelial growth factor-C (VEGF-C) and tumor-associated macrophages in oral cancer (TAMs) with lymph node metastasis. METHOD: From January 2018 to January 2022, 155 cases of oral cancer tissues and 165 cases of normal mucosal tissues were collected from oral surgical resection tissues or biopsy specimens in Hebei Eye Hospital. Oral cancer tissues were observed. The control group had normal mucosal tissues. The clinical and immune parameters were observed and the treatment of oral cancer is also briefly discussed. RESULTS: The number of TAMs and the expression of VEGF-C in oral cancer tissues were significantly higher than those in normal tissues (P < 0.05). The lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the metastatic group were higher than in nonmetastatic group, and the lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the paracancerous tissues were higher than central tumor tissue in the metastatic group (P < 0.05). Univariate analysis showed that the number of TAMs was related to the histological stage and the pathological type of oral cancer (P > 0.05). The expression of VEGF-C was associated with the histological stage of oral cancer (P < 0.05). Compared with the immune function after different treatments, the contents of CD4+ in both groups was higher than before, and the combined treatment group was increased more than single treatment group (P < 0.05). The contents of CD3+ and CD8+ in the two groups were lower than before, and the combined treatment group was decreased higher than combined treatment group (P < 0.05). CONCLUSIONS: The number of TAMs and the expression of VEGF-C in oral cancer tissues are higher than normal tissues. The number of TAMs and the expression of VEGF-C are higher in patients with lymph node metastasis. TAMs and VEGF-C may play an important role in lymph node metastasis of oral cancer. Integrated traditional Chinese and Western medicine can improve the immune function of patients with oral cancer and may improve the therapeutic efficacy.
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spelling pubmed-92563942022-07-06 The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer Yuan, Wei Tan, Tao Liu, Ying Du, Yingjie Zhang, Shengjuan Wang, Junrong Evid Based Complement Alternat Med Research Article OBJECTIVE: To investigate the relationship between vascular endothelial growth factor-C (VEGF-C) and tumor-associated macrophages in oral cancer (TAMs) with lymph node metastasis. METHOD: From January 2018 to January 2022, 155 cases of oral cancer tissues and 165 cases of normal mucosal tissues were collected from oral surgical resection tissues or biopsy specimens in Hebei Eye Hospital. Oral cancer tissues were observed. The control group had normal mucosal tissues. The clinical and immune parameters were observed and the treatment of oral cancer is also briefly discussed. RESULTS: The number of TAMs and the expression of VEGF-C in oral cancer tissues were significantly higher than those in normal tissues (P < 0.05). The lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the metastatic group were higher than in nonmetastatic group, and the lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the paracancerous tissues were higher than central tumor tissue in the metastatic group (P < 0.05). Univariate analysis showed that the number of TAMs was related to the histological stage and the pathological type of oral cancer (P > 0.05). The expression of VEGF-C was associated with the histological stage of oral cancer (P < 0.05). Compared with the immune function after different treatments, the contents of CD4+ in both groups was higher than before, and the combined treatment group was increased more than single treatment group (P < 0.05). The contents of CD3+ and CD8+ in the two groups were lower than before, and the combined treatment group was decreased higher than combined treatment group (P < 0.05). CONCLUSIONS: The number of TAMs and the expression of VEGF-C in oral cancer tissues are higher than normal tissues. The number of TAMs and the expression of VEGF-C are higher in patients with lymph node metastasis. TAMs and VEGF-C may play an important role in lymph node metastasis of oral cancer. Integrated traditional Chinese and Western medicine can improve the immune function of patients with oral cancer and may improve the therapeutic efficacy. Hindawi 2022-06-28 /pmc/articles/PMC9256394/ /pubmed/35800004 http://dx.doi.org/10.1155/2022/9910049 Text en Copyright © 2022 Wei Yuan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yuan, Wei
Tan, Tao
Liu, Ying
Du, Yingjie
Zhang, Shengjuan
Wang, Junrong
The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer
title The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer
title_full The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer
title_fullStr The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer
title_full_unstemmed The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer
title_short The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer
title_sort relationship between vegf-c, tam, and lymph node metastasis in oral cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256394/
https://www.ncbi.nlm.nih.gov/pubmed/35800004
http://dx.doi.org/10.1155/2022/9910049
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