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Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke

BACKGROUND: Neurofilament light chain (NfL) is a biomarker for large-caliber axonal degeneration in the subcortex. The purpose of this research was to examine the relationship between plasma neurofilament light chain (pNfL) and cognitive impairment following a posterior circulation stroke. METHODS:...

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Autores principales: Jiang, Lianyan, Wang, Zhiqiang, Wang, Rongyu, Li, Mao, Zhang, Yaodan, Yang, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256396/
https://www.ncbi.nlm.nih.gov/pubmed/35800005
http://dx.doi.org/10.1155/2022/2466982
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author Jiang, Lianyan
Wang, Zhiqiang
Wang, Rongyu
Li, Mao
Zhang, Yaodan
Yang, Dongdong
author_facet Jiang, Lianyan
Wang, Zhiqiang
Wang, Rongyu
Li, Mao
Zhang, Yaodan
Yang, Dongdong
author_sort Jiang, Lianyan
collection PubMed
description BACKGROUND: Neurofilament light chain (NfL) is a biomarker for large-caliber axonal degeneration in the subcortex. The purpose of this research was to examine the relationship between plasma neurofilament light chain (pNfL) and cognitive impairment following a posterior circulation stroke. METHODS: Patients over the age of 18 with their first-ever acute ischemic stroke (AIS) of the posterior cerebral circulation within 24 h of symptom onset were included from July 1, 2017, to December 31, 2019. Blood samples were collected within 48 h after the stroke. The Montreal Cognitive Assessment (MOCA) (MOCA < 26) was adopted to define poststroke cognitive impairment (PSCI) 90 days after stroke onset. RESULTS: A total of 264 patients were analyzed in this research 101 (38.30%) patients were clinically diagnosed with PSCI. The PNfL concentration was significantly higher in the PSCI group compared with the non-PSCI group (p < 0.001). The pNfL concentration (OR 1.044; p < 0.001) remained to be a significant predictor for PSCI after a multivariable logistic regression analysis, even after adjusting for factors including age, sex, education background (OR 1.044; p < 0.001), baseline NIHSS, infarct volume, and TOAST classification (OR 1.035; p < 0.001). The diagnostic efficacy of pNfL concentration for PSCI was then explored with a ROC analysis. The optimum pNfL concentration threshold was 38.12 pg/ml, with a sensitivity of 78.20%, a specificity of 66.9%, and an AUC of 0.782 (p < 0.001). CONCLUSION: This research showed that pNfL concentration, independent of established conventional risk factors, could predict the cognitive impairment in 90 days following posterior circulation stroke.
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spelling pubmed-92563962022-07-06 Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke Jiang, Lianyan Wang, Zhiqiang Wang, Rongyu Li, Mao Zhang, Yaodan Yang, Dongdong Evid Based Complement Alternat Med Research Article BACKGROUND: Neurofilament light chain (NfL) is a biomarker for large-caliber axonal degeneration in the subcortex. The purpose of this research was to examine the relationship between plasma neurofilament light chain (pNfL) and cognitive impairment following a posterior circulation stroke. METHODS: Patients over the age of 18 with their first-ever acute ischemic stroke (AIS) of the posterior cerebral circulation within 24 h of symptom onset were included from July 1, 2017, to December 31, 2019. Blood samples were collected within 48 h after the stroke. The Montreal Cognitive Assessment (MOCA) (MOCA < 26) was adopted to define poststroke cognitive impairment (PSCI) 90 days after stroke onset. RESULTS: A total of 264 patients were analyzed in this research 101 (38.30%) patients were clinically diagnosed with PSCI. The PNfL concentration was significantly higher in the PSCI group compared with the non-PSCI group (p < 0.001). The pNfL concentration (OR 1.044; p < 0.001) remained to be a significant predictor for PSCI after a multivariable logistic regression analysis, even after adjusting for factors including age, sex, education background (OR 1.044; p < 0.001), baseline NIHSS, infarct volume, and TOAST classification (OR 1.035; p < 0.001). The diagnostic efficacy of pNfL concentration for PSCI was then explored with a ROC analysis. The optimum pNfL concentration threshold was 38.12 pg/ml, with a sensitivity of 78.20%, a specificity of 66.9%, and an AUC of 0.782 (p < 0.001). CONCLUSION: This research showed that pNfL concentration, independent of established conventional risk factors, could predict the cognitive impairment in 90 days following posterior circulation stroke. Hindawi 2022-06-28 /pmc/articles/PMC9256396/ /pubmed/35800005 http://dx.doi.org/10.1155/2022/2466982 Text en Copyright © 2022 Lianyan Jiang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Lianyan
Wang, Zhiqiang
Wang, Rongyu
Li, Mao
Zhang, Yaodan
Yang, Dongdong
Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke
title Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke
title_full Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke
title_fullStr Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke
title_full_unstemmed Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke
title_short Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke
title_sort plasma neurofilament light chain is associated with cognitive impairment after posterior circulation stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256396/
https://www.ncbi.nlm.nih.gov/pubmed/35800005
http://dx.doi.org/10.1155/2022/2466982
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