Effect of Ruanjian Xiaoying Granules on Hashimoto Rats with Depression of Liver and Deficiency of Spleen and Effect on Intestinal Microflora

In order to investigate the effect of Ruanjian Xiaoying Granule, experiments were conducted on the intestinal flora of rats with liver depression and spleen deficiency. 48 SPF grade rats are used as the object, and 12 rats are randomly selected as the normal control group. The Hashimoto rat model of liver depression and spleen deficiency type by drug intervention is constructed by the remaining rats. They are randomly divided into three groups: the model group, the traditional Chinese medicine group, and the Jinshuibao group. The normal group and model group are given 2 ml of distilled water twice a day, and the traditional Chinese medicine group is given the Ruanjian Xiaoying granule group (12.96 g/kg/day) twice a day. The Jinshuibao capsule is dissolved in water and given orally at a dose of 0.45 g/kg/day twice a day. After 12 weeks of intervention, the effect is evaluated, and the levels of serum TGAb, TPOAb, and bacterial diversity are compared. Experimental results show that Ruanjian Xiaoying granules can promote the regulation of flora levels in Hashimoto rats with liver depression and spleen deficiency.