Age-dependent cognitive impairment, hydrocephalus and leukocyte infiltration in transgenic mice with endothelial expression of human EPHX2

Soluble epoxide hydrolase (sEH) is upregulated in microvascular endothelium of human brain with vascular cognitive impairment (VCI). Transgenic endothelial expression of human sEH in mice (Tie2hsEH) induces endothelial dysfunction (ED), a pathogenetic mechanism of VCI. We sought to determine if endo...

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Detalles Bibliográficos
Autores principales: Davis, Catherine M., Zhang, Wenri H., Bah, Thierno M., Roese, Natalie E., Allen, Elyse M., Leung, Philberta, Boutros, Sydney J., Marzulla, Tessa, Patel, Esha, Nie, Xiao, Alkayed, Farah N., Huang, Justin H., Jensen, Michael A., Raber, Jacob, Pike, Martin M., Alkayed, Nabil J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256583/
https://www.ncbi.nlm.nih.gov/pubmed/35927273
http://dx.doi.org/10.1038/s41514-022-00090-1

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