Cargando…

Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

Antivenom is currently the first-choice treatment for snakebite envenoming. However, only a low proportion of antivenom immunoglobulins are specific to venom toxins, resulting in poor dose efficacy and potency. We sought to investigate whether linear venom epitopes displayed on virus like particles...

Descripción completa

Detalles Bibliográficos
Autores principales:	Menzies, Stefanie K., Dawson, Charlotte A., Crittenden, Edouard, Edge, Rebecca J., Hall, Steven R., Alsolaiss, Jaffer, Wilkinson, Mark C., Casewell, Nicholas R., Harrison, Robert A., Ainsworth, Stuart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256628/ https://www.ncbi.nlm.nih.gov/pubmed/35790745 http://dx.doi.org/10.1038/s41598-022-13376-x

Ejemplares similares

Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms
por: Alomran, Nessrin, et al.
Publicado: (2022)

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms
por: Alomran, Nessrin, et al.
Publicado: (2021)

Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms
por: Alomran, Nessrin, et al.
Publicado: (2022)

Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming
por: Alomran, Nessrin, et al.
Publicado: (2022)

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology
por: Alsolaiss, Jaffer, et al.
Publicado: (2022)

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus
por: Menzies, Stefanie K., et al.
Publicado: (2022)

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
por: Albulescu, Laura-Oana, et al.
Publicado: (2020)

Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
por: Albulescu, Laura-Oana, et al.
Publicado: (2021)

Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms
por: Alsolaiss, Jaffer, et al.
Publicado: (2022)

Physiological constraints dictate toxin spatial heterogeneity in snake venom glands
por: Kazandjian, Taline D., et al.
Publicado: (2022)

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms
por: Xie, Chunfang, et al.
Publicado: (2020)

Causes and Consequences of Snake Venom Variation
por: Casewell, Nicholas R., et al.
Publicado: (2020)

Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal
por: Amorim, Fernanda Gobbi, et al.
Publicado: (2023)

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins
por: Xie, Chunfang, et al.
Publicado: (2020)

TOXINS AND ANTITOXINS--SNAKE VENOMS AND ANTIVENINS
por: Madsen, Th., et al.
Publicado: (1907)

Computational Studies of Snake Venom Toxins
por: Ojeda, Paola G., et al.
Publicado: (2017)

In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms
por: Chaisakul, Janeyuth, et al.
Publicado: (2020)

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics
por: Xie, Chunfang, et al.
Publicado: (2020)

Monitoring Snake Venom-Induced Extracellular Matrix Degradation and Identifying Proteolytically Active Venom Toxins Using Fluorescently Labeled Substrates
por: Bittenbinder, Mátyás A., et al.
Publicado: (2023)

Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools
por: Alonso, Luis L., et al.
Publicado: (2023)

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms
por: Ainsworth, Stuart, et al.
Publicado: (2018)

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa
por: Harrison, Robert A., et al.
Publicado: (2017)

Two snakebite antivenoms have potential to reduce Eswatini’s dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing
por: Menzies, Stefanie K., et al.
Publicado: (2022)

Correction: Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa
por: Harrison, Robert A., et al.
Publicado: (2020)

The Influence of the Different Disposition Characteristics of Snake Toxins on the Pharmacokinetics of Snake Venom
por: Sanhajariya, Suchaya, et al.
Publicado: (2020)

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise
por: Slagboom, Julien, et al.
Publicado: (2017)

Investigating Toxin Diversity and Abundance in Snake Venom Proteomes
por: Tasoulis, Theo, et al.
Publicado: (2022)

Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms
por: Madrigal, Marvin, et al.
Publicado: (2017)

Two pathways for venom toxin entry consequent to injection of an Australian elapid snake venom
por: Helden, Dirk F. van, et al.
Publicado: (2019)

Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis
por: O’Brien, Jeffrey, et al.
Publicado: (2018)

Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms
por: Still, Kristina B. M., et al.
Publicado: (2017)

Snakes, Snake Venoms, and Antivenenes
por: Ranck, E. M.
Publicado: (1902)

Evaluation of the geographical utility of Eastern Russell’s viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity
por: Chaisakul, Janeyuth, et al.
Publicado: (2019)

Snake Venoms in Medicine
por: Chopra, R. N., et al.
Publicado: (1932)

Venom-Related Transcripts from Bothrops jararaca Tissues Provide Novel Molecular Insights into the Production and Evolution of Snake Venom
por: Junqueira-de-Azevedo, Inácio L.M., et al.
Publicado: (2015)

Editorial: Novel Immunotherapies Against Envenomings by Snakes and Other Venomous Animals
por: Laustsen, Andreas Hougaard, et al.
Publicado: (2020)

Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins
por: Jackson, Timothy N. W., et al.
Publicado: (2013)

Restriction and Recruitment—Gene Duplication and the Origin and Evolution of Snake Venom Toxins
por: Hargreaves, Adam D., et al.
Publicado: (2014)

Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
por: Moura-da-Silva, Ana M., et al.
Publicado: (2016)

Hyaluronan breakdown by snake venom hyaluronidases: From toxins delivery to immunopathology
por: Silva de França, Felipe, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_48k0gof3bvic8hft27beec34j0