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Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair

DNA ligase I (LIG1) catalyzes the ligation of the nick repair intermediate after gap filling by DNA polymerase (pol) β during downstream steps of the base excision repair (BER) pathway. However, how LIG1 discriminates against the mutagenic 3′-mismatches incorporated by polβ at atomic resolution rema...

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Detalles Bibliográficos
Autores principales:	Tang, Qun, Gulkis, Mitchell, McKenna, Robert, Çağlayan, Melike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256674/ https://www.ncbi.nlm.nih.gov/pubmed/35790757 http://dx.doi.org/10.1038/s41467-022-31585-w

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