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Targeting mitochondrial one-carbon enzyme MTHFD2 together with pemetrexed confers therapeutic advantages in lung adenocarcinoma

Metabolic remodeling is the fundamental molecular feature of malignant tumors. Cancer cells require sufficient energy supplies supporting their high proliferative rate. MTHFD2, a mitochondrial one-carbon metabolic enzyme, is dysregulated in several malignancies and may serve as a promising therapeut...

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Detalles Bibliográficos
Autores principales:	Mo, Juanfen, Gao, Zhenzhen, Zheng, Li, Yan, Miaolong, Xue, Min, Xu, Jianqiu, Bao, Yi, Wu, Jiayuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256677/ https://www.ncbi.nlm.nih.gov/pubmed/35790743 http://dx.doi.org/10.1038/s41420-022-01098-y

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