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Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein

Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively express the high affinity IL-2Rα subunit. However, even low dose IL-2, signaling through the IL2-Rβ/γ complex, may lead to...

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Detalles Bibliográficos
Autores principales:	de Picciotto, Seymour, DeVita, Nicholas, Hsiao, Chiaowen Joyce, Honan, Christopher, Tse, Sze-Wah, Nguyen, Mychael, Ferrari, Joseph D., Zheng, Wei, Wipke, Brian T., Huang, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256694/ https://www.ncbi.nlm.nih.gov/pubmed/35790728 http://dx.doi.org/10.1038/s41467-022-31130-9

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