Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique vulnerabilities in the tumor microenvironment (TME) of EOC have largely been unrealized. One strategy to achieve selective drug delivery for EOC...

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Detalles Bibliográficos
Autores principales: Wallace-Povirk, Adrianne, Rubinsak, Lisa, Malysa, Agnes, Dzinic, Sijana H., Ravindra, Manasa, Schneider, Mathew, Glassbrook, James, O’Connor, Carrie, Hou, Zhanjun, Kim, Seongho, Back, Jessica, Polin, Lisa, Morris, Robert T., Gangjee, Aleem, Gibson, Heather, Matherly, Larry H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256750/
https://www.ncbi.nlm.nih.gov/pubmed/35790779
http://dx.doi.org/10.1038/s41598-022-14788-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256750/
https://www.ncbi.nlm.nih.gov/pubmed/35790779
http://dx.doi.org/10.1038/s41598-022-14788-5

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