Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors

Mesothelin targeting CAR T cells have limited activity in patients. In this study, we sought to determine if efficacy of anti-mesothelin CAR T cells is dependent on the mesothelin epitopes that are recognized by them. To do so, we developed hYP218 (against membrane-proximal epitope) and SS1 (against...

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Detalles Bibliográficos
Autores principales: Tomar, Sakshi, Zhang, Jingli, Khanal, Manakamana, Hong, Jessica, Venugopalan, Abhilash, Jiang, Qun, Sengupta, Manjistha, Miettinen, Markku, Li, Nan, Pastan, Ira, Ho, Mitchell, Hassan, Raffit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Large Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256778/
https://www.ncbi.nlm.nih.gov/pubmed/35499461
http://dx.doi.org/10.1158/1535-7163.MCT-22-0073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256778/
https://www.ncbi.nlm.nih.gov/pubmed/35499461
http://dx.doi.org/10.1158/1535-7163.MCT-22-0073

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