Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Altered metabolism helps sustain cancer cell proliferation and survival. Most cancers, including prostate cancers, express the M2 splice isoform of pyruvate kinase (PKM2), which can support anabolic metabolism to support cell proliferation. However, Pkm2 expression is dispensable for the formation a...

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Detalles Bibliográficos
Autores principales: Davidson, Shawn M., Schmidt, Daniel R., Heyman, Julia E., O'Brien, James P., Liu, Amy C., Israelsen, William J., Dayton, Talya L., Sehgal, Raghav, Bronson, Roderick T., Freinkman, Elizaveta, Mak, Howard H., Fanelli, Giuseppe Nicolò, Malstrom, Scott, Bellinger, Gary, Carracedo, Arkaitz, Pandolfi, Pier Paolo, Courtney, Kevin D., Jha, Abhishek, DePinho, Ronald A., Horner, James W., Thomas, Craig J., Cantley, Lewis C., Loda, Massimo, Vander Heiden, Matthew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Metabolism and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256808/
https://www.ncbi.nlm.nih.gov/pubmed/35584006
http://dx.doi.org/10.1158/0008-5472.CAN-21-2352

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