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SparseSignatures: An R package using LASSO-regularized non-negative matrix factorization to identify mutational signatures from human tumor samples

We outline the features of the R package SparseSignatures and its application to determine the signatures contributing to mutation profiles of tumor samples. We describe installation details and illustrate a step-by-step approach to (1) prepare the data for signature analysis, (2) determine the opti...

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Detalles Bibliográficos
Autores principales:	Mella, Lorenzo, Lal, Avantika, Angaroni, Fabrizio, Maspero, Davide, Piazza, Rocco, Sidow, Arend, Antoniotti, Marco, Graudenzi, Alex, Ramazzotti, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256827/ https://www.ncbi.nlm.nih.gov/pubmed/35779264 http://dx.doi.org/10.1016/j.xpro.2022.101513

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