The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer

Epigenetic modifications are essential mechanism by which to ensure cell homeostasis. One such modification is lysine methylation of nonhistone proteins by SETD7, a mono-methyltransferase containing SET domains. SETD7 methylates over 30 proteins and is thus involved in various classical pathways. As...

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Autores principales: Chiang, Chengyao, Yang, Heng, Zhu, Lizhi, Chen, Chunlan, Chen, Cheng, Zuo, You, Zheng, Duo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256981/
https://www.ncbi.nlm.nih.gov/pubmed/35812730
http://dx.doi.org/10.3389/fgene.2022.918509
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author Chiang, Chengyao
Yang, Heng
Zhu, Lizhi
Chen, Chunlan
Chen, Cheng
Zuo, You
Zheng, Duo
author_facet Chiang, Chengyao
Yang, Heng
Zhu, Lizhi
Chen, Chunlan
Chen, Cheng
Zuo, You
Zheng, Duo
author_sort Chiang, Chengyao
collection PubMed
description Epigenetic modifications are essential mechanism by which to ensure cell homeostasis. One such modification is lysine methylation of nonhistone proteins by SETD7, a mono-methyltransferase containing SET domains. SETD7 methylates over 30 proteins and is thus involved in various classical pathways. As such, SETD7 has been implicated in both the basic functions of normal tissues but also in several pathologies, such as cancers. In this review, we summarize the current knowledge of SETD7 substrates, especially transcriptional-related proteins and enzymes, and their putative roles upon SETD7-mediated methylation. We focus on the role of SETD7 in cancers, and speculate on the possible points of intervention and areas for future research.
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spelling pubmed-92569812022-07-07 The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer Chiang, Chengyao Yang, Heng Zhu, Lizhi Chen, Chunlan Chen, Cheng Zuo, You Zheng, Duo Front Genet Genetics Epigenetic modifications are essential mechanism by which to ensure cell homeostasis. One such modification is lysine methylation of nonhistone proteins by SETD7, a mono-methyltransferase containing SET domains. SETD7 methylates over 30 proteins and is thus involved in various classical pathways. As such, SETD7 has been implicated in both the basic functions of normal tissues but also in several pathologies, such as cancers. In this review, we summarize the current knowledge of SETD7 substrates, especially transcriptional-related proteins and enzymes, and their putative roles upon SETD7-mediated methylation. We focus on the role of SETD7 in cancers, and speculate on the possible points of intervention and areas for future research. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9256981/ /pubmed/35812730 http://dx.doi.org/10.3389/fgene.2022.918509 Text en Copyright © 2022 Chiang, Yang, Zhu, Chen, Chen, Zuo and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Chiang, Chengyao
Yang, Heng
Zhu, Lizhi
Chen, Chunlan
Chen, Cheng
Zuo, You
Zheng, Duo
The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer
title The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer
title_full The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer
title_fullStr The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer
title_full_unstemmed The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer
title_short The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer
title_sort epigenetic regulation of nonhistone proteins by setd7: new targets in cancer
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256981/
https://www.ncbi.nlm.nih.gov/pubmed/35812730
http://dx.doi.org/10.3389/fgene.2022.918509
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