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The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients

Carnosine is a dipeptide expressed in both the central nervous system and periphery. Several biological functions have been attributed to carnosine, including as an anti-inflammatory and antioxidant agent, and as a modulator of mitochondrial metabolism. Some of these mechanisms have been implicated...

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Autores principales: Diniz, Fabiola Cardoso, Hipkiss, Alan Roger, Ferreira, Gustavo Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257001/
https://www.ncbi.nlm.nih.gov/pubmed/35812220
http://dx.doi.org/10.3389/fnins.2022.898735
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author Diniz, Fabiola Cardoso
Hipkiss, Alan Roger
Ferreira, Gustavo Costa
author_facet Diniz, Fabiola Cardoso
Hipkiss, Alan Roger
Ferreira, Gustavo Costa
author_sort Diniz, Fabiola Cardoso
collection PubMed
description Carnosine is a dipeptide expressed in both the central nervous system and periphery. Several biological functions have been attributed to carnosine, including as an anti-inflammatory and antioxidant agent, and as a modulator of mitochondrial metabolism. Some of these mechanisms have been implicated in the pathophysiology of coronavirus disease-2019 (COVID-19). COVID-19 is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The clinical manifestation and recovery time for COVID-19 are variable. Some patients are severely affected by SARS-CoV-2 infection and may experience respiratory failure, thromboembolic disease, neurological symptoms, kidney damage, acute pancreatitis, and even death. COVID-19 patients with comorbidities, including diabetes, are at higher risk of death. Mechanisms underlying the dysfunction of the afflicted organs in COVID-19 patients have been discussed, the most common being the so-called cytokine storm. Given the biological effects attributed to carnosine, adjuvant therapy with this dipeptide could be considered as supportive treatment in patients with either COVID-19 or long COVID.
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spelling pubmed-92570012022-07-07 The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients Diniz, Fabiola Cardoso Hipkiss, Alan Roger Ferreira, Gustavo Costa Front Neurosci Neuroscience Carnosine is a dipeptide expressed in both the central nervous system and periphery. Several biological functions have been attributed to carnosine, including as an anti-inflammatory and antioxidant agent, and as a modulator of mitochondrial metabolism. Some of these mechanisms have been implicated in the pathophysiology of coronavirus disease-2019 (COVID-19). COVID-19 is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The clinical manifestation and recovery time for COVID-19 are variable. Some patients are severely affected by SARS-CoV-2 infection and may experience respiratory failure, thromboembolic disease, neurological symptoms, kidney damage, acute pancreatitis, and even death. COVID-19 patients with comorbidities, including diabetes, are at higher risk of death. Mechanisms underlying the dysfunction of the afflicted organs in COVID-19 patients have been discussed, the most common being the so-called cytokine storm. Given the biological effects attributed to carnosine, adjuvant therapy with this dipeptide could be considered as supportive treatment in patients with either COVID-19 or long COVID. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9257001/ /pubmed/35812220 http://dx.doi.org/10.3389/fnins.2022.898735 Text en Copyright © 2022 Diniz, Hipkiss and Ferreira. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Diniz, Fabiola Cardoso
Hipkiss, Alan Roger
Ferreira, Gustavo Costa
The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients
title The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients
title_full The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients
title_fullStr The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients
title_full_unstemmed The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients
title_short The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients
title_sort potential use of carnosine in diabetes and other afflictions reported in long covid patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257001/
https://www.ncbi.nlm.nih.gov/pubmed/35812220
http://dx.doi.org/10.3389/fnins.2022.898735
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