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Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease
The intestinal microbiome plays an essential role in human health and disease status. So far, microbiota transplantation is considered a potential therapeutic approach for treating some chronic diseases, including inflammatory bowel disease (IBD). The diversity of gut microbiota is critical for main...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257068/ https://www.ncbi.nlm.nih.gov/pubmed/35811664 http://dx.doi.org/10.3389/fcimb.2022.916543 |
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author | Wang, Xiaoli Zhao, Jingwen Feng, Yuanhang Feng, Zelin Ye, Yulin Liu, Limin Kang, Guangbo Cao, Xiaocang |
author_facet | Wang, Xiaoli Zhao, Jingwen Feng, Yuanhang Feng, Zelin Ye, Yulin Liu, Limin Kang, Guangbo Cao, Xiaocang |
author_sort | Wang, Xiaoli |
collection | PubMed |
description | The intestinal microbiome plays an essential role in human health and disease status. So far, microbiota transplantation is considered a potential therapeutic approach for treating some chronic diseases, including inflammatory bowel disease (IBD). The diversity of gut microbiota is critical for maintaining resilience, and therefore, transplantation with numerous genetically diverse gut microbiota with metabolic flexibility and functional redundancy can effectively improve gut health than a single probiotic strain supplement. Studies have shown that natural fecal microbiota transplantation or washing microbiota transplantation can alleviate colitis and improve intestinal dysbiosis in IBD patients. However, unexpected adverse reactions caused by the complex and unclear composition of the flora limit its wider application. The evolving strain isolation technology and modifiable pre-existing strains are driving the development of microbiota transplantation. This review summarized the updating clinical and preclinical data of IBD treatments from fecal microbiota transplantation to washing microbiota transplantation, and then to artificial consortium transplantation. In addition, the factors considered for strain combination were reviewed. Furthermore, four types of artificial consortium transplant products were collected to analyze their combination and possible compatibility principles. The perspective on individualized microbiota transplantation was also discussed ultimately. |
format | Online Article Text |
id | pubmed-9257068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92570682022-07-07 Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease Wang, Xiaoli Zhao, Jingwen Feng, Yuanhang Feng, Zelin Ye, Yulin Liu, Limin Kang, Guangbo Cao, Xiaocang Front Cell Infect Microbiol Cellular and Infection Microbiology The intestinal microbiome plays an essential role in human health and disease status. So far, microbiota transplantation is considered a potential therapeutic approach for treating some chronic diseases, including inflammatory bowel disease (IBD). The diversity of gut microbiota is critical for maintaining resilience, and therefore, transplantation with numerous genetically diverse gut microbiota with metabolic flexibility and functional redundancy can effectively improve gut health than a single probiotic strain supplement. Studies have shown that natural fecal microbiota transplantation or washing microbiota transplantation can alleviate colitis and improve intestinal dysbiosis in IBD patients. However, unexpected adverse reactions caused by the complex and unclear composition of the flora limit its wider application. The evolving strain isolation technology and modifiable pre-existing strains are driving the development of microbiota transplantation. This review summarized the updating clinical and preclinical data of IBD treatments from fecal microbiota transplantation to washing microbiota transplantation, and then to artificial consortium transplantation. In addition, the factors considered for strain combination were reviewed. Furthermore, four types of artificial consortium transplant products were collected to analyze their combination and possible compatibility principles. The perspective on individualized microbiota transplantation was also discussed ultimately. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9257068/ /pubmed/35811664 http://dx.doi.org/10.3389/fcimb.2022.916543 Text en Copyright © 2022 Wang, Zhao, Feng, Feng, Ye, Liu, Kang and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Wang, Xiaoli Zhao, Jingwen Feng, Yuanhang Feng, Zelin Ye, Yulin Liu, Limin Kang, Guangbo Cao, Xiaocang Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease |
title | Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease |
title_full | Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease |
title_fullStr | Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease |
title_full_unstemmed | Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease |
title_short | Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease |
title_sort | evolutionary insights into microbiota transplantation in inflammatory bowel disease |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257068/ https://www.ncbi.nlm.nih.gov/pubmed/35811664 http://dx.doi.org/10.3389/fcimb.2022.916543 |
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