Cargando…

Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy

Based on the safety of prussian blue (PB) in biomedical application, we prepared manganese-based prussian blue (MnPB) nanocatalysts to achieve enhanced photothermal therapy and chemodynamic therapy. And we conducted a series of experiments to explore the therapeutic effects of MnPB nanoparticles (NP...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Danruo, Liu, Zeyu, Jin, Hansong, Huang, Xiulin, Shi, Yongxin, Ben, Suqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257087/
https://www.ncbi.nlm.nih.gov/pubmed/35814022
http://dx.doi.org/10.3389/fbioe.2022.939158
_version_ 1784741261712818176
author Fang, Danruo
Liu, Zeyu
Jin, Hansong
Huang, Xiulin
Shi, Yongxin
Ben, Suqin
author_facet Fang, Danruo
Liu, Zeyu
Jin, Hansong
Huang, Xiulin
Shi, Yongxin
Ben, Suqin
author_sort Fang, Danruo
collection PubMed
description Based on the safety of prussian blue (PB) in biomedical application, we prepared manganese-based prussian blue (MnPB) nanocatalysts to achieve enhanced photothermal therapy and chemodynamic therapy. And we conducted a series of experiments to explore the therapeutic effects of MnPB nanoparticles (NPs) on non-small cell lung cancer (NSCLC) in vivo and in vitro. For in vitro experiments, the MnPB NPs suppressed growth of A549 cells by reactive oxygen species upregulation and near-infrared irradiation. Moreover, the MnPB NPs could inhibit lung cancer metastasis through downregulating the matrix metalloproteinase (MMP)-2 and MMP-9 expression in A549 cells. And for in vivo experiments, the MnPB NPs inhibited the growth of xenografted tumor effectively and were biologically safe. Meanwhile, Mn(2+) as a T1-weighted agent could realize magnetic resonance imaging-guided diagnosis and treatment. To sum up, the results in this study clearly demonstrated that the MnPB NPs had remarkable effects for inhibiting the growth and metastasis of NSCLC and might serve as a promising multifunctional nanoplatform for NSCLC treatment.
format Online
Article
Text
id pubmed-9257087
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92570872022-07-07 Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy Fang, Danruo Liu, Zeyu Jin, Hansong Huang, Xiulin Shi, Yongxin Ben, Suqin Front Bioeng Biotechnol Bioengineering and Biotechnology Based on the safety of prussian blue (PB) in biomedical application, we prepared manganese-based prussian blue (MnPB) nanocatalysts to achieve enhanced photothermal therapy and chemodynamic therapy. And we conducted a series of experiments to explore the therapeutic effects of MnPB nanoparticles (NPs) on non-small cell lung cancer (NSCLC) in vivo and in vitro. For in vitro experiments, the MnPB NPs suppressed growth of A549 cells by reactive oxygen species upregulation and near-infrared irradiation. Moreover, the MnPB NPs could inhibit lung cancer metastasis through downregulating the matrix metalloproteinase (MMP)-2 and MMP-9 expression in A549 cells. And for in vivo experiments, the MnPB NPs inhibited the growth of xenografted tumor effectively and were biologically safe. Meanwhile, Mn(2+) as a T1-weighted agent could realize magnetic resonance imaging-guided diagnosis and treatment. To sum up, the results in this study clearly demonstrated that the MnPB NPs had remarkable effects for inhibiting the growth and metastasis of NSCLC and might serve as a promising multifunctional nanoplatform for NSCLC treatment. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9257087/ /pubmed/35814022 http://dx.doi.org/10.3389/fbioe.2022.939158 Text en Copyright © 2022 Fang, Liu, Jin, Huang, Shi and Ben. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Fang, Danruo
Liu, Zeyu
Jin, Hansong
Huang, Xiulin
Shi, Yongxin
Ben, Suqin
Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy
title Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy
title_full Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy
title_fullStr Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy
title_full_unstemmed Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy
title_short Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy
title_sort manganese-based prussian blue nanocatalysts suppress non-small cell lung cancer growth and metastasis via photothermal and chemodynamic therapy
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257087/
https://www.ncbi.nlm.nih.gov/pubmed/35814022
http://dx.doi.org/10.3389/fbioe.2022.939158
work_keys_str_mv AT fangdanruo manganesebasedprussianbluenanocatalystssuppressnonsmallcelllungcancergrowthandmetastasisviaphotothermalandchemodynamictherapy
AT liuzeyu manganesebasedprussianbluenanocatalystssuppressnonsmallcelllungcancergrowthandmetastasisviaphotothermalandchemodynamictherapy
AT jinhansong manganesebasedprussianbluenanocatalystssuppressnonsmallcelllungcancergrowthandmetastasisviaphotothermalandchemodynamictherapy
AT huangxiulin manganesebasedprussianbluenanocatalystssuppressnonsmallcelllungcancergrowthandmetastasisviaphotothermalandchemodynamictherapy
AT shiyongxin manganesebasedprussianbluenanocatalystssuppressnonsmallcelllungcancergrowthandmetastasisviaphotothermalandchemodynamictherapy
AT bensuqin manganesebasedprussianbluenanocatalystssuppressnonsmallcelllungcancergrowthandmetastasisviaphotothermalandchemodynamictherapy