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RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies
By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or sometimes even completely avoided. Stimulating NAMs may...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257167/ https://www.ncbi.nlm.nih.gov/pubmed/35814243 http://dx.doi.org/10.3389/fphar.2022.930148 |
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author | Van Mulders, Mieke Liodo Missigba, Nancy Mertens, Birgit Rogiers, Vera |
author_facet | Van Mulders, Mieke Liodo Missigba, Nancy Mertens, Birgit Rogiers, Vera |
author_sort | Van Mulders, Mieke |
collection | PubMed |
description | By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or sometimes even completely avoided. Stimulating NAMs may benefit from a bottom-up approach, i.e., local initiatives mapping the available NAMs and promoting their use. An example of such an initiative in Belgium is the RE-Place project, which collects the available NAMs in one central database, and links this knowledge with the names of experts and research centers. To this extent, a template was created to collect the information of interest in a fast and consistent manner. Based on this template, a web-based application was developed to facilitate the entry of information, which was evaluated in a pilot study by experts in the field of NAMs. After integration of their feedback, a revised version of the RE-Place online tool was launched to the public. Aspects such as user-friendliness, quality of submitted information, protection of personal data and Intellectual Property (IP) rights were all considered in the development process. Hurdles like incentives for collaboration were also taken into account. Information submitted with the online tool is directly integrated in the RE-Place open access database. By consulting the database, scientists from various disciplines can easily identify the different types of NAMs and the experts using them in Belgium. As such, the RE-Place database contributes to building trust in the use of NAMs and stimulating their use and regulatory uptake. |
format | Online Article Text |
id | pubmed-9257167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92571672022-07-07 RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies Van Mulders, Mieke Liodo Missigba, Nancy Mertens, Birgit Rogiers, Vera Front Pharmacol Pharmacology By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or sometimes even completely avoided. Stimulating NAMs may benefit from a bottom-up approach, i.e., local initiatives mapping the available NAMs and promoting their use. An example of such an initiative in Belgium is the RE-Place project, which collects the available NAMs in one central database, and links this knowledge with the names of experts and research centers. To this extent, a template was created to collect the information of interest in a fast and consistent manner. Based on this template, a web-based application was developed to facilitate the entry of information, which was evaluated in a pilot study by experts in the field of NAMs. After integration of their feedback, a revised version of the RE-Place online tool was launched to the public. Aspects such as user-friendliness, quality of submitted information, protection of personal data and Intellectual Property (IP) rights were all considered in the development process. Hurdles like incentives for collaboration were also taken into account. Information submitted with the online tool is directly integrated in the RE-Place open access database. By consulting the database, scientists from various disciplines can easily identify the different types of NAMs and the experts using them in Belgium. As such, the RE-Place database contributes to building trust in the use of NAMs and stimulating their use and regulatory uptake. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9257167/ /pubmed/35814243 http://dx.doi.org/10.3389/fphar.2022.930148 Text en Copyright © 2022 Van Mulders, Liodo Missigba, Mertens and Rogiers. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Van Mulders, Mieke Liodo Missigba, Nancy Mertens, Birgit Rogiers, Vera RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies |
title | RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies |
title_full | RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies |
title_fullStr | RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies |
title_full_unstemmed | RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies |
title_short | RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies |
title_sort | re-place: a unique project collecting expertise on new approach methodologies |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257167/ https://www.ncbi.nlm.nih.gov/pubmed/35814243 http://dx.doi.org/10.3389/fphar.2022.930148 |
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