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Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial

Lutein was shown to provide health benefits for a few diseases. The dose-response relation of oral lutein intake in humans has rarely been reported. The objective is to investigate the dose-response relation between oral lutein intake and plasma lutein concentration in humans. Forty subjects were re...

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Autores principales: Xiong, Ke, Zhao, Yanhui, Hu, Shouna, Ma, Aiguo, Ma, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257170/
https://www.ncbi.nlm.nih.gov/pubmed/35811994
http://dx.doi.org/10.3389/fnut.2022.924997
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author Xiong, Ke
Zhao, Yanhui
Hu, Shouna
Ma, Aiguo
Ma, Yan
author_facet Xiong, Ke
Zhao, Yanhui
Hu, Shouna
Ma, Aiguo
Ma, Yan
author_sort Xiong, Ke
collection PubMed
description Lutein was shown to provide health benefits for a few diseases. The dose-response relation of oral lutein intake in humans has rarely been reported. The objective is to investigate the dose-response relation between oral lutein intake and plasma lutein concentration in humans. Forty subjects were recruited from Qingdao University, China in 2014. The subjects were randomly divided into four groups: (1–3) consuming 10, 20, or 40 mg lutein by one, two, or four capsules of lutein A, respectively; (4) consuming 20 mg lutein by two capsules of lutein B (containing 280 mg n-3 fatty acid). After a single oral dose, plasma lutein concentrations were measured at 9-time points. The raise of plasma lutein concentration by a 40 mg dose was significantly higher than by a 10 or 20 mg dose. Plasma lutein concentrations were not significantly different between taking 20 mg lutein A and 20 mg lutein B. A dose-response relation was demonstrated between oral lutein administration and plasma lutein concentration. The dose-response relation was more pronounced among men. The current work provides a scientific basis for recommending a dietary intake level of lutein. Future work should validate the results in other ethnic and age groups.
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spelling pubmed-92571702022-07-07 Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial Xiong, Ke Zhao, Yanhui Hu, Shouna Ma, Aiguo Ma, Yan Front Nutr Nutrition Lutein was shown to provide health benefits for a few diseases. The dose-response relation of oral lutein intake in humans has rarely been reported. The objective is to investigate the dose-response relation between oral lutein intake and plasma lutein concentration in humans. Forty subjects were recruited from Qingdao University, China in 2014. The subjects were randomly divided into four groups: (1–3) consuming 10, 20, or 40 mg lutein by one, two, or four capsules of lutein A, respectively; (4) consuming 20 mg lutein by two capsules of lutein B (containing 280 mg n-3 fatty acid). After a single oral dose, plasma lutein concentrations were measured at 9-time points. The raise of plasma lutein concentration by a 40 mg dose was significantly higher than by a 10 or 20 mg dose. Plasma lutein concentrations were not significantly different between taking 20 mg lutein A and 20 mg lutein B. A dose-response relation was demonstrated between oral lutein administration and plasma lutein concentration. The dose-response relation was more pronounced among men. The current work provides a scientific basis for recommending a dietary intake level of lutein. Future work should validate the results in other ethnic and age groups. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9257170/ /pubmed/35811994 http://dx.doi.org/10.3389/fnut.2022.924997 Text en Copyright © 2022 Xiong, Zhao, Hu, Ma and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Xiong, Ke
Zhao, Yanhui
Hu, Shouna
Ma, Aiguo
Ma, Yan
Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial
title Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial
title_full Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial
title_fullStr Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial
title_full_unstemmed Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial
title_short Dose-Response Relationship Between Oral Lutein Intake and Plasma Lutein Concentration: A Randomized Controlled Trial
title_sort dose-response relationship between oral lutein intake and plasma lutein concentration: a randomized controlled trial
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257170/
https://www.ncbi.nlm.nih.gov/pubmed/35811994
http://dx.doi.org/10.3389/fnut.2022.924997
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