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Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology

INTRODUCTION: Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non‐invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. METHODS: Intensity‐based...

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Autores principales: Abdelhak, Ahmed, Solomon, Isaac, Montes, Shivany Condor, Saias, Alexandra, Cordano, Christian, Asken, Breton, Fonseca, Corrina, Oertel, Frederike Cosima, Arfanakis, Konstantinos, Staffaroni, Adam M., Kramer, Joel H., Geschwind, Michael, Miller, Bruce L., Elahi, Fanny M., Green, Ari J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257197/
https://www.ncbi.nlm.nih.gov/pubmed/35814617
http://dx.doi.org/10.1002/dad2.12338
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author Abdelhak, Ahmed
Solomon, Isaac
Montes, Shivany Condor
Saias, Alexandra
Cordano, Christian
Asken, Breton
Fonseca, Corrina
Oertel, Frederike Cosima
Arfanakis, Konstantinos
Staffaroni, Adam M.
Kramer, Joel H.
Geschwind, Michael
Miller, Bruce L.
Elahi, Fanny M.
Green, Ari J.
author_facet Abdelhak, Ahmed
Solomon, Isaac
Montes, Shivany Condor
Saias, Alexandra
Cordano, Christian
Asken, Breton
Fonseca, Corrina
Oertel, Frederike Cosima
Arfanakis, Konstantinos
Staffaroni, Adam M.
Kramer, Joel H.
Geschwind, Michael
Miller, Bruce L.
Elahi, Fanny M.
Green, Ari J.
author_sort Abdelhak, Ahmed
collection PubMed
description INTRODUCTION: Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non‐invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. METHODS: Intensity‐based retinal arteriolar visualization in optical coherence tomography (I‐bRAVO) was applied to evaluate mean wall thickness (MWT) and wall‐to‐lumen ratio (WLR) in 250 subjects with sporadic and genetic cerebral small vessel disease (CSVD), non‐vascular neurodegenerative diseases (NVND), and healthy controls (HC) in association with imaging and cognitive markers. RESULTS: MWT and WLR were higher in CSVD, associated with severity of vascular white matter lesions, and correlated with magnetic resonance imaging‐based intracranial arteriolosclerosis score. WLR correlated with gray and white matter volume and differentiated asymptomatic sporadic CSVD from HC (area under the curve = 0.82). DISCUSSION: I‐bRAVO is a rapid, non‐invasive tool. MWT and WLR were associated with imaging markers of CSVD and could contribute to early identification of sporadic CSVD.
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spelling pubmed-92571972022-07-08 Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology Abdelhak, Ahmed Solomon, Isaac Montes, Shivany Condor Saias, Alexandra Cordano, Christian Asken, Breton Fonseca, Corrina Oertel, Frederike Cosima Arfanakis, Konstantinos Staffaroni, Adam M. Kramer, Joel H. Geschwind, Michael Miller, Bruce L. Elahi, Fanny M. Green, Ari J. Alzheimers Dement (Amst) Retinal Imaging INTRODUCTION: Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non‐invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. METHODS: Intensity‐based retinal arteriolar visualization in optical coherence tomography (I‐bRAVO) was applied to evaluate mean wall thickness (MWT) and wall‐to‐lumen ratio (WLR) in 250 subjects with sporadic and genetic cerebral small vessel disease (CSVD), non‐vascular neurodegenerative diseases (NVND), and healthy controls (HC) in association with imaging and cognitive markers. RESULTS: MWT and WLR were higher in CSVD, associated with severity of vascular white matter lesions, and correlated with magnetic resonance imaging‐based intracranial arteriolosclerosis score. WLR correlated with gray and white matter volume and differentiated asymptomatic sporadic CSVD from HC (area under the curve = 0.82). DISCUSSION: I‐bRAVO is a rapid, non‐invasive tool. MWT and WLR were associated with imaging markers of CSVD and could contribute to early identification of sporadic CSVD. John Wiley and Sons Inc. 2022-07-05 /pmc/articles/PMC9257197/ /pubmed/35814617 http://dx.doi.org/10.1002/dad2.12338 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Retinal Imaging
Abdelhak, Ahmed
Solomon, Isaac
Montes, Shivany Condor
Saias, Alexandra
Cordano, Christian
Asken, Breton
Fonseca, Corrina
Oertel, Frederike Cosima
Arfanakis, Konstantinos
Staffaroni, Adam M.
Kramer, Joel H.
Geschwind, Michael
Miller, Bruce L.
Elahi, Fanny M.
Green, Ari J.
Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
title Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
title_full Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
title_fullStr Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
title_full_unstemmed Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
title_short Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
title_sort retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
topic Retinal Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257197/
https://www.ncbi.nlm.nih.gov/pubmed/35814617
http://dx.doi.org/10.1002/dad2.12338
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