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Profiling Differential Effects of 5 Selective Serotonin Reuptake Inhibitors on TLRs-Dependent and -Independent IL-6 Production in Immune Cells Identifies Fluoxetine as Preferred Anti-Inflammatory Drug Candidate

Excessive proinflammatory cytokine production induced by abnormal activation of Toll-like receptor (TLR) signaling, for example, by SARS-CoV-2 infection, can cause a fatal cytokine storm. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine, used to treat depression, were r...

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Detalles Bibliográficos
Autores principales:	Takenaka, Yohei, Tanaka, Ryu, Kitabatake, Kazuki, Kuramochi, Kouji, Aoki, Shin, Tsukimoto, Mitsutoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257214/ https://www.ncbi.nlm.nih.gov/pubmed/35814203 http://dx.doi.org/10.3389/fphar.2022.874375

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