Distinct Contribution of Global and Regional Angiotensin II Type 1a Receptor Inactivation to Amelioration of Aortopathy in Tgfbr1(M318R/+) Mice

Angiotensin II (Ang II) type 1 receptor (AT1R) signaling controls both physiological and pathogenetic responses in the vasculature. In mouse models of Loeys-Dietz syndrome (LDS), a hereditary disorder characterized by aggressive aortic aneurysms, treatment with angiotensin receptor blockers (ARBs) p...

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Detalles Bibliográficos
Autores principales: Bramel, Emily E., Bagirzadeh, Rustam, Saqib, Muzna, Creamer, Tyler J., Espinoza Camejo, Wendy A., Roker, LaToya Ann, Pardo Habashi, Jennifer, Dietz, Harry C., Gallo MacFarlane, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257222/
https://www.ncbi.nlm.nih.gov/pubmed/35811726
http://dx.doi.org/10.3389/fcvm.2022.936142

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