Cargando…

Design and synthesis of hybrid compounds as novel drugs and medicines

The development of highly effective conjugate chemistry approaches is a way to improve the quality of drugs and of medicines. The aim of this paper is to highlight and review such hybrid compounds and the strategies underpinning their design. A variety of unique hybrid compounds provide an excellent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alkhzem, Abdulaziz H., Woodman, Timothy J., Blagbrough, Ian S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257310/ https://www.ncbi.nlm.nih.gov/pubmed/35865575 http://dx.doi.org/10.1039/d2ra03281c

Ejemplares similares

Practical Synthesis of Polyamine Succinamides and Branched Polyamines
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2022)

Individual pK(a) Values of Tobramycin, Kanamycin B, Amikacin, Sisomicin, and Netilmicin Determined by Multinuclear NMR Spectroscopy
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2020)

Multinuclear Nuclear Magnetic Resonance Spectroscopy Is Used to Determine Rapidly and Accurately the Individual pK(a) Values of 2-Deoxystreptamine, Neamine, Neomycin, Paromomycin, and Streptomycin
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2021)

Practical Synthesis of Antimicrobial Long Linear Polyamine Succinamides
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2022)

Antibacterial activity of novel linear polyamines against Staphylococcus aureus
por: Douglas, Edward J. A., et al.
Publicado: (2022)

Computer-aided drug design, synthesis and identification of disulfide compounds as novel and potential allosteric PAK1 inhibitors
por: Huang, Hanwei, et al.
Publicado: (2018)

Design, synthesis and evaluation of a myricetin and nobiletin hybrid compound for alleviating hyperuricemia based on metabolomics and gut microbiota
por: Li, Yan, et al.
Publicado: (2023)

Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2
por: Tantawy, Ahmed H., et al.
Publicado: (2021)

Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids
por: Pazhanivel, Lakshmanan, et al.
Publicado: (2018)

Design and Synthesis of Hybrid Compounds as Epigenetic Modifiers
por: Lopes, Juliana Romano, et al.
Publicado: (2021)

Design, synthesis and biological activity evaluation of benzoate compounds as local anesthetics
por: Zou, Huiying, et al.
Publicado: (2019)

Design, synthesis and cytotoxic evaluation of a library of oxadiazole-containing hybrids
por: Camacho, Cristián M., et al.
Publicado: (2021)

The (1)H NMR Spectroscopic Effect of Steric Compression Is Found in [3.3.1]Oxa- and Azabicycles and Their Analogues
por: Zeng, Ziyu, et al.
Publicado: (2021)

Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA
por: Mohamed, Asmaa H., et al.
Publicado: (2023)

Synthesis and biological evaluation of novel artemisone–piperazine–tetronamide hybrids
por: Wei, Meng-Xue, et al.
Publicado: (2021)

Design, synthesis, anticancer and in silico assessment of 8-caffeinyl-triazolylmethoxy hybrid conjugates
por: Soltani Rad, Mohammad Navid, et al.
Publicado: (2023)

Design, synthesis and biological evaluation of a novel colchicine-magnolol hybrid for inhibiting the growth of Lewis lung carcinoma in Vitro and in Vivo
por: Li, Zhiyue, et al.
Publicado: (2022)

Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity
por: Cundy, Nicholas J., et al.
Publicado: (2021)

Impacts of Steric Compression, Protonation, and Intramolecular Hydrogen Bonding on the (15)N NMR Spectroscopy of Norditerpenoid Alkaloids and Their Piperidine-Ring Analogues
por: Zeng, Ziyu, et al.
Publicado: (2020)

Novel Stilbene-Nitroxyl Hybrid Compounds Display Discrete Modulation of Amyloid Beta Toxicity and Structure
por: Hilt, Silvia, et al.
Publicado: (2022)

A concise and sequential synthesis of the nitroimidazooxazole based drug, Delamanid and related compounds
por: Sharma, Sumit, et al.
Publicado: (2020)

Design and Synthesis of Chitosan—Gelatin Hybrid Hydrogels for 3D Printable in vitro Models
por: Magli, Sofia, et al.
Publicado: (2020)

Design, synthesis, anticancer and in silico assessment of 8-piperazinyl caffeinyl-triazolylmethyl hybrid conjugates
por: Soltani Rad, Mohammad Navid, et al.
Publicado: (2023)

Non-covalent interactions in the synthesis and design of new compounds
por: Maharramov, Abel M, et al.
Publicado: (2016)

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation
por: Aziz, Yasmine M. Abdel, et al.
Publicado: (2021)

Microwave-assisted synthesis, computational studies and antibacterial/ anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid
por: Chavan, Rakesh R., et al.
Publicado: (2018)

Facile synthesis of indole heterocyclic compounds based micellar nano anti-cancer drugs
por: Ali, Imran, et al.
Publicado: (2018)

Enzymatic synthesis of novel fructosylated compounds by Ffase from Schwanniomyces occidentalis in green solvents
por: Piedrabuena, David, et al.
Publicado: (2021)

The 1α-hydroxy-A-rings of norditerpenoid alkaloids are twisted-boat conformers
por: Zeng, Ziyu, et al.
Publicado: (2020)

Natural products in drug discovery and development: Synthesis and medicinal perspective of leonurine
por: Li, Zhaoyi, et al.
Publicado: (2022)

Design and Synthesis of Novel Antileishmanial Compounds
por: Loedige, Melanie
Publicado: (2015)

New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies
por: Syam, Yasmin M., et al.
Publicado: (2021)

Novel Carbonyl Analogs of Tamoxifen: Design, Synthesis, and Biological Evaluation
por: Kasiotis, Konstantinos M., et al.
Publicado: (2017)

Editorial: Design, Synthesis, and Application of Novel π-Conjugated Materials
por: Dai, Zhicheng, et al.
Publicado: (2021)

Synthesis of novel naphthalene-heterocycle hybrids with potent antitumor, anti-inflammatory and antituberculosis activities
por: Abozeid, Mohamed Ahmed, et al.
Publicado: (2020)

Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies
por: Tariq, Hafiza Zara, et al.
Publicado: (2023)

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9
por: Kandimalla, Ekambar R., et al.
Publicado: (2013)

Greener synthesis of chemical compounds and materials
por: Kharissova, Oxana V., et al.
Publicado: (2019)

Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies
por: Malik, M. Shaheer, et al.
Publicado: (2021)

Design, synthesis and in silico screening of benzoxazole–thiazolidinone hybrids as potential inhibitors of SARS-CoV-2 proteases
por: Krishna Cheerala, Vijay Sai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c8qaduf1c5olhklmd97ac4mboe