Tumor cell-conditioned media drives collagen remodeling via fibroblast and pericyte activation in an in vitro premetastatic niche model

Primary tumors secrete large quantities of cytokines and exosomes into the bloodstream, which are uptaken at downstream sites and induce a pro-fibrotic, pro-inflammatory premetastatic niche. Niche development is associated with later increased metastatic burden, but the cellular and matrix changes i...

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Detalles Bibliográficos
Autores principales: Nairon, Kylie G., DePalma, Thomas J., Zent, Joshua M., Leight, Jennifer L., Skardal, Aleksander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257340/
https://www.ncbi.nlm.nih.gov/pubmed/35811850
http://dx.doi.org/10.1016/j.isci.2022.104645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257340/
https://www.ncbi.nlm.nih.gov/pubmed/35811850
http://dx.doi.org/10.1016/j.isci.2022.104645

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