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Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks

Topoisomerase II Binding Protein 1 (TOPBP1) is an important activator of the DNA damage response kinase Ataxia Telangiectasia and Rad3-related (ATR), although the mechanism by which this activation occurs is not yet known. TOPBP1 contains nine copies of the BRCA1 C-terminal repeat (BRCT) motif, whic...

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Detalles Bibliográficos
Autores principales:	Ruis, Kenna, Huynh, Oanh, Montales, Katrina, Barr, Nina A., Michael, W. Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257406/ https://www.ncbi.nlm.nih.gov/pubmed/35490781 http://dx.doi.org/10.1016/j.jbc.2022.101992

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