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Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva
As the most commonly used antipyretic and analgesic drug, paracetamol (PA) coexists with neurotransmitter dopamine (DA) in real biological samples. Their simultaneous determination is extremely important for human health, but they also interfere with each other. In order to improve the conductivity,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Xi'an Jiaotong University
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257442/ https://www.ncbi.nlm.nih.gov/pubmed/35811619 http://dx.doi.org/10.1016/j.jpha.2021.08.005 |
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author | Yang, Hui Cao, Gongxun Huang, Yongjun Lin, Ye Zheng, Fengying Lin, Luxiu Liu, Fengjiao Li, Shunxing |
author_facet | Yang, Hui Cao, Gongxun Huang, Yongjun Lin, Ye Zheng, Fengying Lin, Luxiu Liu, Fengjiao Li, Shunxing |
author_sort | Yang, Hui |
collection | PubMed |
description | As the most commonly used antipyretic and analgesic drug, paracetamol (PA) coexists with neurotransmitter dopamine (DA) in real biological samples. Their simultaneous determination is extremely important for human health, but they also interfere with each other. In order to improve the conductivity, adsorption affinity, sensitivity, and selectivity of TiO(2)-based electrochemical sensor, N-doped carbon@TiO(2) double-shelled hollow sphere (H–C/N@TiO(2)) is designed and synthesized by simple alcoholic and hydrothermal method, using polystyrene sphere (PS) as a template. Meanwhile, TiO(2) hollow spheres (H–TiO(2)) or N-doped carbon hollow spheres (H–C/N) are also prepared by the same method. H–C/N@TiO(2) has good conductivity, charge separation, and the highly enhanced and stable current responses for the detection of PA and DA. The detection limit and linear range are 50.0 nmol/L and 0.3–50 μmol/L for PA, 40.0 nmol/L and 0.3–50 μmol/L for DA, respectively, which are better than those of carbon-based sensors. Moreover, this electrochemical sensor, with high selectivity, strong anti-interference, high reliability, and long time durability, can be used for the simultaneous detection of PA and DA in human blood serum and saliva. The high electrochemical performance of H–C/N@TiO(2) is attributed to the multi-functional combination of different layers, because of good conductivity, absorption and electrons transfer ability from in-situ N-doped carbon and electrocatalytic activity from TiO(2). |
format | Online Article Text |
id | pubmed-9257442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Xi'an Jiaotong University |
record_format | MEDLINE/PubMed |
spelling | pubmed-92574422022-07-08 Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva Yang, Hui Cao, Gongxun Huang, Yongjun Lin, Ye Zheng, Fengying Lin, Luxiu Liu, Fengjiao Li, Shunxing J Pharm Anal Original Article As the most commonly used antipyretic and analgesic drug, paracetamol (PA) coexists with neurotransmitter dopamine (DA) in real biological samples. Their simultaneous determination is extremely important for human health, but they also interfere with each other. In order to improve the conductivity, adsorption affinity, sensitivity, and selectivity of TiO(2)-based electrochemical sensor, N-doped carbon@TiO(2) double-shelled hollow sphere (H–C/N@TiO(2)) is designed and synthesized by simple alcoholic and hydrothermal method, using polystyrene sphere (PS) as a template. Meanwhile, TiO(2) hollow spheres (H–TiO(2)) or N-doped carbon hollow spheres (H–C/N) are also prepared by the same method. H–C/N@TiO(2) has good conductivity, charge separation, and the highly enhanced and stable current responses for the detection of PA and DA. The detection limit and linear range are 50.0 nmol/L and 0.3–50 μmol/L for PA, 40.0 nmol/L and 0.3–50 μmol/L for DA, respectively, which are better than those of carbon-based sensors. Moreover, this electrochemical sensor, with high selectivity, strong anti-interference, high reliability, and long time durability, can be used for the simultaneous detection of PA and DA in human blood serum and saliva. The high electrochemical performance of H–C/N@TiO(2) is attributed to the multi-functional combination of different layers, because of good conductivity, absorption and electrons transfer ability from in-situ N-doped carbon and electrocatalytic activity from TiO(2). Xi'an Jiaotong University 2022-06 2021-09-01 /pmc/articles/PMC9257442/ /pubmed/35811619 http://dx.doi.org/10.1016/j.jpha.2021.08.005 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Yang, Hui Cao, Gongxun Huang, Yongjun Lin, Ye Zheng, Fengying Lin, Luxiu Liu, Fengjiao Li, Shunxing Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva |
title | Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva |
title_full | Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva |
title_fullStr | Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva |
title_full_unstemmed | Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva |
title_short | Nitrogen-doped carbon@TiO(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva |
title_sort | nitrogen-doped carbon@tio(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257442/ https://www.ncbi.nlm.nih.gov/pubmed/35811619 http://dx.doi.org/10.1016/j.jpha.2021.08.005 |
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