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Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines, tested...

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Autores principales: Silva, Ihatanderson A., Lima, Ana Luiza, Gratieri, Tais, Gelfuso, Guilherme M., Sa-Barreto, Livia L., Cunha-Filho, Marcilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257448/
https://www.ncbi.nlm.nih.gov/pubmed/35811629
http://dx.doi.org/10.1016/j.jpha.2021.09.010
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author Silva, Ihatanderson A.
Lima, Ana Luiza
Gratieri, Tais
Gelfuso, Guilherme M.
Sa-Barreto, Livia L.
Cunha-Filho, Marcilio
author_facet Silva, Ihatanderson A.
Lima, Ana Luiza
Gratieri, Tais
Gelfuso, Guilherme M.
Sa-Barreto, Livia L.
Cunha-Filho, Marcilio
author_sort Silva, Ihatanderson A.
collection PubMed
description One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines, tested regarding their morphology and thermal, crystallographic, and spectroscopic profiles. Generally, despite the strong drug-polymer interactions observed, the chemical stability of the model drugs was preserved under such conditions. In fact, in the metoprolol and Soluplus® composition, the drug's solubilization in the polymer produced a delay in the drug decomposition, suggesting a protective effect of the matrix. Paracetamol and polyvinyl alcohol mixture, in turn, showed unmistakable signs of thermal instability and chemical decomposition, in addition to physical changes. In the presented context, establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.
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spelling pubmed-92574482022-07-08 Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines Silva, Ihatanderson A. Lima, Ana Luiza Gratieri, Tais Gelfuso, Guilherme M. Sa-Barreto, Livia L. Cunha-Filho, Marcilio J Pharm Anal Original Article One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines, tested regarding their morphology and thermal, crystallographic, and spectroscopic profiles. Generally, despite the strong drug-polymer interactions observed, the chemical stability of the model drugs was preserved under such conditions. In fact, in the metoprolol and Soluplus® composition, the drug's solubilization in the polymer produced a delay in the drug decomposition, suggesting a protective effect of the matrix. Paracetamol and polyvinyl alcohol mixture, in turn, showed unmistakable signs of thermal instability and chemical decomposition, in addition to physical changes. In the presented context, establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology. Xi'an Jiaotong University 2022-06 2021-09-20 /pmc/articles/PMC9257448/ /pubmed/35811629 http://dx.doi.org/10.1016/j.jpha.2021.09.010 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Silva, Ihatanderson A.
Lima, Ana Luiza
Gratieri, Tais
Gelfuso, Guilherme M.
Sa-Barreto, Livia L.
Cunha-Filho, Marcilio
Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines
title Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines
title_full Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines
title_fullStr Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines
title_full_unstemmed Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines
title_short Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines
title_sort compatibility and stability studies involving polymers used in fused deposition modeling 3d printing of medicines
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257448/
https://www.ncbi.nlm.nih.gov/pubmed/35811629
http://dx.doi.org/10.1016/j.jpha.2021.09.010
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