Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE)

Identifying new binding sites and poses that modify biological function are an important step towards drug discovery. We have identified a novel disulphide constrained peptide that interacts with the cap-binding site of eIF4E, an attractive therapeutic target that is commonly overexpressed in many c...

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Detalles Bibliográficos
Autores principales: Frosi, Yuri, Ng, Simon, Lin, Yen-Chu, Jiang, Shimin, Ramlan, Siti Radhiah, Lama, Dilraj, Verma, Chandra S., Asial, Ignacio, Brown, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257606/
https://www.ncbi.nlm.nih.gov/pubmed/35866173
http://dx.doi.org/10.1039/d2cb00099g

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