A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy

Herein we report a dual-responsive doxorubicin–indoximod conjugate (DOXIND) for programmed chemoimmunotherapy. This conjugate is able to release doxorubicin and indoximod upon exposure to appropriate stimuli for synergistic chemotherapy and immunotherapy, respectively. We demonstrate its promoting e...

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Detalles Bibliográficos
Autores principales: Yang, Zhaoxuan, Huang, Jiaqi, Lin, Yaying, Luo, Xiangjie, Lin, Haojin, Lin, Hongyu, Gao, Jinhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257650/
https://www.ncbi.nlm.nih.gov/pubmed/35866166
http://dx.doi.org/10.1039/d1cb00257k
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author Yang, Zhaoxuan
Huang, Jiaqi
Lin, Yaying
Luo, Xiangjie
Lin, Haojin
Lin, Hongyu
Gao, Jinhao
author_facet Yang, Zhaoxuan
Huang, Jiaqi
Lin, Yaying
Luo, Xiangjie
Lin, Haojin
Lin, Hongyu
Gao, Jinhao
author_sort Yang, Zhaoxuan
collection PubMed
description Herein we report a dual-responsive doxorubicin–indoximod conjugate (DOXIND) for programmed chemoimmunotherapy. This conjugate is able to release doxorubicin and indoximod upon exposure to appropriate stimuli for synergistic chemotherapy and immunotherapy, respectively. We demonstrate its promoting effects on immune response and inhibiting effects on tumor growth through a series of in vitro and in vivo experiments.
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spelling pubmed-92576502022-07-20 A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy Yang, Zhaoxuan Huang, Jiaqi Lin, Yaying Luo, Xiangjie Lin, Haojin Lin, Hongyu Gao, Jinhao RSC Chem Biol Chemistry Herein we report a dual-responsive doxorubicin–indoximod conjugate (DOXIND) for programmed chemoimmunotherapy. This conjugate is able to release doxorubicin and indoximod upon exposure to appropriate stimuli for synergistic chemotherapy and immunotherapy, respectively. We demonstrate its promoting effects on immune response and inhibiting effects on tumor growth through a series of in vitro and in vivo experiments. RSC 2022-05-30 /pmc/articles/PMC9257650/ /pubmed/35866166 http://dx.doi.org/10.1039/d1cb00257k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yang, Zhaoxuan
Huang, Jiaqi
Lin, Yaying
Luo, Xiangjie
Lin, Haojin
Lin, Hongyu
Gao, Jinhao
A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
title A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
title_full A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
title_fullStr A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
title_full_unstemmed A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
title_short A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
title_sort dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257650/
https://www.ncbi.nlm.nih.gov/pubmed/35866166
http://dx.doi.org/10.1039/d1cb00257k
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