Binding of the Dual-Action Anti-Parkinsonian Drug AG-0029 to Dopamine D(2) and Histamine H(3) Receptors: A PET Study in Healthy Rats

[Image: see text] Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor dysfunction and a diverse range of nonmotor symptoms. Functional relationships between the dopaminergic and histaminergic systems suggest that dual-action pharmaceuticals like AG-0029 (D(2...

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Autores principales: Ghazanfari, Nafiseh, van Waarde, Aren, Doorduin, Janine, Sijbesma, Jürgen W. A., Kominia, Maria, Koelewijn, Martin, Attia, Khaled, Vállez-García, David, Willemsen, Antoon T. M., Heeres, André, Dierckx, Rudi A. J. O., Visser, Ton J., de Vries, Erik F. J., Elsinga, Philip H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257755/
https://www.ncbi.nlm.nih.gov/pubmed/35732005
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00121

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