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REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

Vascular dementia (VD) and Alzheimer’s disease (AD) are common types of dementia for which no curative therapies are known. In this study, we identified hub genes associated with AD and VD in order to explore new potential therapeutic targets. Genes differentially expressed in VD and AD in all three...

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Autores principales: Luo, Jiefeng, Chen, Liechun, Huang, Xiaohua, Xie, Jieqiong, Zou, Chun, Pan, Mika, Mo, Jingjia, Zou, Donghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257827/
https://www.ncbi.nlm.nih.gov/pubmed/35813961
http://dx.doi.org/10.3389/fnagi.2022.894824
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author Luo, Jiefeng
Chen, Liechun
Huang, Xiaohua
Xie, Jieqiong
Zou, Chun
Pan, Mika
Mo, Jingjia
Zou, Donghua
author_facet Luo, Jiefeng
Chen, Liechun
Huang, Xiaohua
Xie, Jieqiong
Zou, Chun
Pan, Mika
Mo, Jingjia
Zou, Donghua
author_sort Luo, Jiefeng
collection PubMed
description Vascular dementia (VD) and Alzheimer’s disease (AD) are common types of dementia for which no curative therapies are known. In this study, we identified hub genes associated with AD and VD in order to explore new potential therapeutic targets. Genes differentially expressed in VD and AD in all three datasets (GSE122063, GSE132903, and GSE5281) were identified and used to construct a protein–protein interaction network. We identified 10 modules containing 427 module genes in AD and VD. Module genes showing an area under the diagnostic curve > 0.60 for AD or VD were used to construct a least absolute shrinkage and selection operator model and were entered into a support vector machine-recursive feature elimination algorithm, which identified REPS1 as a hub gene in AD and VD. Furthermore, REPS1 was associated with activation of pyruvate metabolism and inhibition of Ras signaling pathway. Module genes, together with differentially expressed microRNAs from the dataset GSE46579, were used to construct a regulatory network. REPS1 was predicted to bind to the microRNA hsa_miR_5701. Single-sample gene set enrichment analysis was used to explore immune cell infiltration, which suggested a negative correlation between REPS1 expression and infiltration by plasmacytoid dendritic cells in AD and VD. In conclusion, our results suggest core pathways involved in both AD and VD, and they identify REPS1 as a potential biomarker of both diseases. This protein may aid in early diagnosis, monitoring of treatment response, and even efforts to prevent these debilitating disorders.
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spelling pubmed-92578272022-07-07 REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia Luo, Jiefeng Chen, Liechun Huang, Xiaohua Xie, Jieqiong Zou, Chun Pan, Mika Mo, Jingjia Zou, Donghua Front Aging Neurosci Neuroscience Vascular dementia (VD) and Alzheimer’s disease (AD) are common types of dementia for which no curative therapies are known. In this study, we identified hub genes associated with AD and VD in order to explore new potential therapeutic targets. Genes differentially expressed in VD and AD in all three datasets (GSE122063, GSE132903, and GSE5281) were identified and used to construct a protein–protein interaction network. We identified 10 modules containing 427 module genes in AD and VD. Module genes showing an area under the diagnostic curve > 0.60 for AD or VD were used to construct a least absolute shrinkage and selection operator model and were entered into a support vector machine-recursive feature elimination algorithm, which identified REPS1 as a hub gene in AD and VD. Furthermore, REPS1 was associated with activation of pyruvate metabolism and inhibition of Ras signaling pathway. Module genes, together with differentially expressed microRNAs from the dataset GSE46579, were used to construct a regulatory network. REPS1 was predicted to bind to the microRNA hsa_miR_5701. Single-sample gene set enrichment analysis was used to explore immune cell infiltration, which suggested a negative correlation between REPS1 expression and infiltration by plasmacytoid dendritic cells in AD and VD. In conclusion, our results suggest core pathways involved in both AD and VD, and they identify REPS1 as a potential biomarker of both diseases. This protein may aid in early diagnosis, monitoring of treatment response, and even efforts to prevent these debilitating disorders. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9257827/ /pubmed/35813961 http://dx.doi.org/10.3389/fnagi.2022.894824 Text en Copyright © 2022 Luo, Chen, Huang, Xie, Zou, Pan, Mo and Zou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Luo, Jiefeng
Chen, Liechun
Huang, Xiaohua
Xie, Jieqiong
Zou, Chun
Pan, Mika
Mo, Jingjia
Zou, Donghua
REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia
title REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia
title_full REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia
title_fullStr REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia
title_full_unstemmed REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia
title_short REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia
title_sort reps1 as a potential biomarker in alzheimer’s disease and vascular dementia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257827/
https://www.ncbi.nlm.nih.gov/pubmed/35813961
http://dx.doi.org/10.3389/fnagi.2022.894824
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