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Identification of potent aldose reductase inhibitors as antidiabetic (Anti-hyperglycemic) agents using QSAR based virtual Screening, molecular Docking, MD simulation and MMGBSA approaches

The aldose reductase (AR) enzyme is an important target enzyme in the development of therapeutics against hyperglycaemia induced health complications such as retinopathy, etc. In the present study, a quantitative structure activity relationship (QSAR) evaluation of a dataset of 226 reported AR inhib...

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Detalles Bibliográficos
Autores principales:	Bakal, Ravindra L., Jawarkar, Rahul D., Manwar, J.V., Jaiswal, Minal S., Ghosh, Arabinda, Gandhi, Ajaykumar, Zaki, Magdi E.A., Al-Hussain, Sami, Samad, Abdul, Masand, Vijay H., Mukerjee, Nobendu, Nasir Abbas Bukhari, Syed, Sharma, Praveen, Lewaa, Israa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257878/ https://www.ncbi.nlm.nih.gov/pubmed/35812153 http://dx.doi.org/10.1016/j.jsps.2022.04.003

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