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Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center

OBJECTIVES: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome. METHODS: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identifi...

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Autores principales: Alanazi, Ghalib M., ALOsaimi, Turki F., Alwadei, Ali H., Al-Otaibi, Ali D., Jad, Lamya A., Al-Attas, Alawi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Riyadh : Armed Forces Hospital 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257907/
https://www.ncbi.nlm.nih.gov/pubmed/35477916
http://dx.doi.org/10.17712/nsj.2022.2.20210135
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author Alanazi, Ghalib M.
ALOsaimi, Turki F.
Alwadei, Ali H.
Al-Otaibi, Ali D.
Jad, Lamya A.
Al-Attas, Alawi A.
author_facet Alanazi, Ghalib M.
ALOsaimi, Turki F.
Alwadei, Ali H.
Al-Otaibi, Ali D.
Jad, Lamya A.
Al-Attas, Alawi A.
author_sort Alanazi, Ghalib M.
collection PubMed
description OBJECTIVES: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome. METHODS: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox–Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8±1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8±3.9 years were implanted with VNS stimulators. RESULTS: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75% seizure reduction in more than 50% in one, and greater than 25% in 2 respectively. However, in those implanted with VNS, 2 (50%) patients achieved a reduction in seizure frequency of greater than 75% and 2 (50%) greater than 25%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS. CONCLUSION: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients.
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spelling pubmed-92579072022-07-14 Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center Alanazi, Ghalib M. ALOsaimi, Turki F. Alwadei, Ali H. Al-Otaibi, Ali D. Jad, Lamya A. Al-Attas, Alawi A. Neurosciences (Riyadh) Original Article OBJECTIVES: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome. METHODS: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox–Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8±1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8±3.9 years were implanted with VNS stimulators. RESULTS: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75% seizure reduction in more than 50% in one, and greater than 25% in 2 respectively. However, in those implanted with VNS, 2 (50%) patients achieved a reduction in seizure frequency of greater than 75% and 2 (50%) greater than 25%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS. CONCLUSION: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients. Riyadh : Armed Forces Hospital 2022-04 /pmc/articles/PMC9257907/ /pubmed/35477916 http://dx.doi.org/10.17712/nsj.2022.2.20210135 Text en Copyright: © Neurosciences https://creativecommons.org/licenses/by-nc/3.0/Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Article
Alanazi, Ghalib M.
ALOsaimi, Turki F.
Alwadei, Ali H.
Al-Otaibi, Ali D.
Jad, Lamya A.
Al-Attas, Alawi A.
Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center
title Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center
title_full Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center
title_fullStr Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center
title_full_unstemmed Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center
title_short Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome: Experience of a tertiary care center
title_sort efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with lennox–gastaut syndrome: experience of a tertiary care center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257907/
https://www.ncbi.nlm.nih.gov/pubmed/35477916
http://dx.doi.org/10.17712/nsj.2022.2.20210135
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