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The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity

Polycystic ovary syndrome (PCOS) is a polyendocrine disorder and the most common endocrinopathy in women of reproductive age. Affected women have an elevated prevalence of being overweight and obese. Our study sought to determine how weight loss associated with lifestyle changes affects the endometr...

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Autores principales: Abdulkhalikova, D., Sustarsic, A., Vrtačnik Bokal, Eda, Jancar, N., Jensterle, M., Burnik Papler, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258031/
https://www.ncbi.nlm.nih.gov/pubmed/35813634
http://dx.doi.org/10.3389/fendo.2022.888460
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author Abdulkhalikova, D.
Sustarsic, A.
Vrtačnik Bokal, Eda
Jancar, N.
Jensterle, M.
Burnik Papler, T.
author_facet Abdulkhalikova, D.
Sustarsic, A.
Vrtačnik Bokal, Eda
Jancar, N.
Jensterle, M.
Burnik Papler, T.
author_sort Abdulkhalikova, D.
collection PubMed
description Polycystic ovary syndrome (PCOS) is a polyendocrine disorder and the most common endocrinopathy in women of reproductive age. Affected women have an elevated prevalence of being overweight and obese. Our study sought to determine how weight loss associated with lifestyle changes affects the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. A group of 12 infertile women under the age of 38 with PCOS and BMI ≥30 kg/m(2) were included in the study. An evaluation was performed by a gynecologist and an endocrinologist. The weight-loss program lasted 8 weeks under the guidance of a professional trainer. Endometrial sampling during a period of implantation window for proteome determination was performed before and after weight loss. In endometrial samples at the end of the study increased protein abundance was recorded for Legumain, Insulin-like growth factor-binding protein 7, Hepatocyte growth factor receptor, Keratin, type II cytoskeletal 7, and Cystatin-B, while the B-lymphocyte antigen CD20 protein abundance decreased. Our results also indicate significantly lowered fasting blood glucose level and free testosterone concentration and significant improvements in body composition and physical capacity. This study may open up the venues for investigating important biomarkers that may affect endometrial receptivity. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT04989244?term=NCT04989244&draw=2&rank=1, identifier: NCT04989244.
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spelling pubmed-92580312022-07-07 The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity Abdulkhalikova, D. Sustarsic, A. Vrtačnik Bokal, Eda Jancar, N. Jensterle, M. Burnik Papler, T. Front Endocrinol (Lausanne) Endocrinology Polycystic ovary syndrome (PCOS) is a polyendocrine disorder and the most common endocrinopathy in women of reproductive age. Affected women have an elevated prevalence of being overweight and obese. Our study sought to determine how weight loss associated with lifestyle changes affects the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. A group of 12 infertile women under the age of 38 with PCOS and BMI ≥30 kg/m(2) were included in the study. An evaluation was performed by a gynecologist and an endocrinologist. The weight-loss program lasted 8 weeks under the guidance of a professional trainer. Endometrial sampling during a period of implantation window for proteome determination was performed before and after weight loss. In endometrial samples at the end of the study increased protein abundance was recorded for Legumain, Insulin-like growth factor-binding protein 7, Hepatocyte growth factor receptor, Keratin, type II cytoskeletal 7, and Cystatin-B, while the B-lymphocyte antigen CD20 protein abundance decreased. Our results also indicate significantly lowered fasting blood glucose level and free testosterone concentration and significant improvements in body composition and physical capacity. This study may open up the venues for investigating important biomarkers that may affect endometrial receptivity. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT04989244?term=NCT04989244&draw=2&rank=1, identifier: NCT04989244. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9258031/ /pubmed/35813634 http://dx.doi.org/10.3389/fendo.2022.888460 Text en Copyright © 2022 Abdulkhalikova, Sustarsic, Vrtačnik Bokal, Jancar, Jensterle and Burnik Papler https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Abdulkhalikova, D.
Sustarsic, A.
Vrtačnik Bokal, Eda
Jancar, N.
Jensterle, M.
Burnik Papler, T.
The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity
title The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity
title_full The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity
title_fullStr The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity
title_full_unstemmed The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity
title_short The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity
title_sort lifestyle modifications and endometrial proteome changes of women with polycystic ovary syndrome and obesity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258031/
https://www.ncbi.nlm.nih.gov/pubmed/35813634
http://dx.doi.org/10.3389/fendo.2022.888460
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