Diversity in EWAS: current state, challenges, and solutions

Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generatio...

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Detalles Bibliográficos
Autores principales: Breeze, Charles E., Wong, Jason Y. Y., Beck, Stephan, Berndt, Sonja I., Franceschini, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258042/
https://www.ncbi.nlm.nih.gov/pubmed/35794667
http://dx.doi.org/10.1186/s13073-022-01065-3
Descripción
Sumario:Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.

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