Diversity in EWAS: current state, challenges, and solutions

Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generatio...

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Autores principales: Breeze, Charles E., Wong, Jason Y. Y., Beck, Stephan, Berndt, Sonja I., Franceschini, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258042/
https://www.ncbi.nlm.nih.gov/pubmed/35794667
http://dx.doi.org/10.1186/s13073-022-01065-3
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author Breeze, Charles E.
Wong, Jason Y. Y.
Beck, Stephan
Berndt, Sonja I.
Franceschini, Nora
author_facet Breeze, Charles E.
Wong, Jason Y. Y.
Beck, Stephan
Berndt, Sonja I.
Franceschini, Nora
author_sort Breeze, Charles E.
collection PubMed
description Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.
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spelling pubmed-92580422022-07-07 Diversity in EWAS: current state, challenges, and solutions Breeze, Charles E. Wong, Jason Y. Y. Beck, Stephan Berndt, Sonja I. Franceschini, Nora Genome Med Comment Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis. BioMed Central 2022-07-06 /pmc/articles/PMC9258042/ /pubmed/35794667 http://dx.doi.org/10.1186/s13073-022-01065-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Comment
Breeze, Charles E.
Wong, Jason Y. Y.
Beck, Stephan
Berndt, Sonja I.
Franceschini, Nora
Diversity in EWAS: current state, challenges, and solutions
title Diversity in EWAS: current state, challenges, and solutions
title_full Diversity in EWAS: current state, challenges, and solutions
title_fullStr Diversity in EWAS: current state, challenges, and solutions
title_full_unstemmed Diversity in EWAS: current state, challenges, and solutions
title_short Diversity in EWAS: current state, challenges, and solutions
title_sort diversity in ewas: current state, challenges, and solutions
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258042/
https://www.ncbi.nlm.nih.gov/pubmed/35794667
http://dx.doi.org/10.1186/s13073-022-01065-3
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