A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression

Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, Samadian, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258118/
https://www.ncbi.nlm.nih.gov/pubmed/35790972
http://dx.doi.org/10.1186/s12935-022-02644-5
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Samadian, Mohammad
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Samadian, Mohammad
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR-876-5p, miR-543-3p, miR-28-5p, miR-93, miR-545, miR-599, miR‐193a‐5p, miR-363-5p, miR-204-5p, miR-211-5p, miR-15a, miR-708-5p, miR-138, miR-138-5p, miR-34a, miR-211, miR‐340‐5p, miR-148a, miR-195-5p and miR-126. Some cancer-related signaling pathway, namely PTEN/AKT, PI3K/AKT and ERK1/2 are influenced by this lncRNA. Cell line studies, animal studies and clinical studies have consistently reported oncogenic role of MCM3AP-AS1 in different tissues except for cervical cancer in which this lncRNA has tumor suppressor role. In the current manuscript, we collected evidence from these three sources of evidence to review the impact of MCM3AP-AS1 in the carcinogenesis.
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spelling pubmed-92581182022-07-07 A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Taheri, Mohammad Samadian, Mohammad Cancer Cell Int Review Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR-876-5p, miR-543-3p, miR-28-5p, miR-93, miR-545, miR-599, miR‐193a‐5p, miR-363-5p, miR-204-5p, miR-211-5p, miR-15a, miR-708-5p, miR-138, miR-138-5p, miR-34a, miR-211, miR‐340‐5p, miR-148a, miR-195-5p and miR-126. Some cancer-related signaling pathway, namely PTEN/AKT, PI3K/AKT and ERK1/2 are influenced by this lncRNA. Cell line studies, animal studies and clinical studies have consistently reported oncogenic role of MCM3AP-AS1 in different tissues except for cervical cancer in which this lncRNA has tumor suppressor role. In the current manuscript, we collected evidence from these three sources of evidence to review the impact of MCM3AP-AS1 in the carcinogenesis. BioMed Central 2022-07-05 /pmc/articles/PMC9258118/ /pubmed/35790972 http://dx.doi.org/10.1186/s12935-022-02644-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Samadian, Mohammad
A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
title A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
title_full A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
title_fullStr A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
title_full_unstemmed A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
title_short A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
title_sort review on the role of mcm3ap-as1 in the carcinogenesis and tumor progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258118/
https://www.ncbi.nlm.nih.gov/pubmed/35790972
http://dx.doi.org/10.1186/s12935-022-02644-5
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