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Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation of alpha-synuclein (aSyn) within neurons in the brain. Predominately pre-synaptic, aSyn has been reported in various subcellular compartments in experimental models. Indeed, nuclear alpha-synuclein (aSyn(Nuc))...

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Detalles Bibliográficos
Autores principales:	Koss, David J., Erskine, Daniel, Porter, Andrew, Palmoski, Pawel, Menon, Hariharan, Todd, Olivia G. J., Leite, Marta, Attems, Johannes, Outeiro, Tiago F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258129/ https://www.ncbi.nlm.nih.gov/pubmed/35794636 http://dx.doi.org/10.1186/s40478-022-01403-x

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