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Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation

BACKGROUND: Autophagy plays a critical role in drug resistance in acute myeloid leukemia (AML), including the subtype with FLT3-ITD mutation. Yet how autophagy is activated and mediates resistance to FLT3 inhibitors in FLT3-ITD-positive AML remains unsure. METHODS: We detected the expression of auto...

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Detalles Bibliográficos
Autores principales:	Xu, Dan, Chen, Yishan, Yang, Ying, Yin, Zhao, Huang, Changfen, Wang, Qiang, Jiang, Ling, Jiang, Xuejie, Yin, Changxin, Liu, Qifa, Yu, Guopan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258138/ https://www.ncbi.nlm.nih.gov/pubmed/35794565 http://dx.doi.org/10.1186/s12967-022-03498-1

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