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Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective
As a common and serious psychiatric disorder, depression significantly affects psychosocial functioning and quality of life. However, the mechanism of depression is still enigmatic and perplexing, which limits its precise and effective therapeutic methods. Recent studies demonstrated that neuroinfla...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258272/ https://www.ncbi.nlm.nih.gov/pubmed/35978968 http://dx.doi.org/10.5498/wjp.v12.i6.779 |
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author | Wang, Shu Guan, Yu-Guang Zhu, Yan-Hua Wang, Min-Zhong |
author_facet | Wang, Shu Guan, Yu-Guang Zhu, Yan-Hua Wang, Min-Zhong |
author_sort | Wang, Shu |
collection | PubMed |
description | As a common and serious psychiatric disorder, depression significantly affects psychosocial functioning and quality of life. However, the mechanism of depression is still enigmatic and perplexing, which limits its precise and effective therapeutic methods. Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression. In this respect, high mobility group box 1 (HMGB1) may be a possible signaling inducer of neuroinflammation and can be a potential mechanistic and therapeutic target for depression. Herein, we review recent studies on the mechanistic and therapeutic targets of HMGB1 in depression and propose potential perspectives on this topic. |
format | Online Article Text |
id | pubmed-9258272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-92582722022-08-16 Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective Wang, Shu Guan, Yu-Guang Zhu, Yan-Hua Wang, Min-Zhong World J Psychiatry Minireviews As a common and serious psychiatric disorder, depression significantly affects psychosocial functioning and quality of life. However, the mechanism of depression is still enigmatic and perplexing, which limits its precise and effective therapeutic methods. Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression. In this respect, high mobility group box 1 (HMGB1) may be a possible signaling inducer of neuroinflammation and can be a potential mechanistic and therapeutic target for depression. Herein, we review recent studies on the mechanistic and therapeutic targets of HMGB1 in depression and propose potential perspectives on this topic. Baishideng Publishing Group Inc 2022-06-19 /pmc/articles/PMC9258272/ /pubmed/35978968 http://dx.doi.org/10.5498/wjp.v12.i6.779 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Wang, Shu Guan, Yu-Guang Zhu, Yan-Hua Wang, Min-Zhong Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective |
title | Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective |
title_full | Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective |
title_fullStr | Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective |
title_full_unstemmed | Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective |
title_short | Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective |
title_sort | role of high mobility group box protein 1 in depression: a mechanistic and therapeutic perspective |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258272/ https://www.ncbi.nlm.nih.gov/pubmed/35978968 http://dx.doi.org/10.5498/wjp.v12.i6.779 |
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