Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma

Small interfering RNA (siRNA)-mediated gene silencing is a promising therapeutic approach. Herein, we report the ambient synthesis of a positively charged iminium-linked covalent organic framework by a three-component one-pot reaction. Through anion exchange and siRNA adsorption, the resulting multi...

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Detalles Bibliográficos
Autores principales: Zhou, Le-Le, Guan, Qun, Zhou, Wei, Kan, Jing-Lan, Dong, Yu-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258322/
https://www.ncbi.nlm.nih.gov/pubmed/35865896
http://dx.doi.org/10.1039/d2sc02297d
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author Zhou, Le-Le
Guan, Qun
Zhou, Wei
Kan, Jing-Lan
Dong, Yu-Bin
author_facet Zhou, Le-Le
Guan, Qun
Zhou, Wei
Kan, Jing-Lan
Dong, Yu-Bin
author_sort Zhou, Le-Le
collection PubMed
description Small interfering RNA (siRNA)-mediated gene silencing is a promising therapeutic approach. Herein, we report the ambient synthesis of a positively charged iminium-linked covalent organic framework by a three-component one-pot reaction. Through anion exchange and siRNA adsorption, the resulting multifunctional siRNA@ABMBP-COF, which possesses both the HK2 inhibitor 3-bromopyruvate and SLC7A11 siRNA, exhibits powerful synergistic antitumor activity against fibrosarcoma via the ferroptosis and apoptosis pathways.
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spelling pubmed-92583222022-07-20 Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma Zhou, Le-Le Guan, Qun Zhou, Wei Kan, Jing-Lan Dong, Yu-Bin Chem Sci Chemistry Small interfering RNA (siRNA)-mediated gene silencing is a promising therapeutic approach. Herein, we report the ambient synthesis of a positively charged iminium-linked covalent organic framework by a three-component one-pot reaction. Through anion exchange and siRNA adsorption, the resulting multifunctional siRNA@ABMBP-COF, which possesses both the HK2 inhibitor 3-bromopyruvate and SLC7A11 siRNA, exhibits powerful synergistic antitumor activity against fibrosarcoma via the ferroptosis and apoptosis pathways. The Royal Society of Chemistry 2022-06-15 /pmc/articles/PMC9258322/ /pubmed/35865896 http://dx.doi.org/10.1039/d2sc02297d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhou, Le-Le
Guan, Qun
Zhou, Wei
Kan, Jing-Lan
Dong, Yu-Bin
Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma
title Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma
title_full Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma
title_fullStr Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma
title_full_unstemmed Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma
title_short Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma
title_sort ambient synthesis of an iminium-linked covalent organic framework for synergetic rna interference and metabolic therapy of fibrosarcoma
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258322/
https://www.ncbi.nlm.nih.gov/pubmed/35865896
http://dx.doi.org/10.1039/d2sc02297d
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