Aberrant neural activity in prefrontal pyramidal neurons lacking TDP-43 precedes neuron loss

Mislocalization of TAR DNA binding protein 43 kDa (TARDBP, or TDP-43) is a principal pathological hallmark identified in cases of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As an RNA binding protein, TDP-43 serves in the nuclear compart...

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Detalles Bibliográficos
Autores principales: Liang, Bo, Thapa, Rashmi, Zhang, Gracie, Moffitt, Casey, Zhang, Yan, Zhang, Lifeng, Johnston, Amanda, Ruby, Hyrum P., Barbera, Giovanni, Wong, Philip C., Zhang, Zhaojie, Chen, Rong, Lin, Da-Ting, Li, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258405/
https://www.ncbi.nlm.nih.gov/pubmed/35667630
http://dx.doi.org/10.1016/j.pneurobio.2022.102297

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