T helper profile in pregnant women recovered from COVID-19

T helper (Th) cell subsets play distinct and important roles during pregnancy. This work was focused on investigating the Th and cytokine profile in pregnant women recovered from COVID-19. To this aim, the frequency of Th1, Th2, Th17 subsets and the level of associated cytokines were analysed in pre...

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Autores principales: Tartaglia, Eleonora, Bordoni, Veronica, Oliva, Alessandra, Vergori, Alessandra, Girardi, Enrico, Antinori, Andrea, Agrati, Chiara, Liuzzi, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258427/
https://www.ncbi.nlm.nih.gov/pubmed/35839525
http://dx.doi.org/10.1016/j.jri.2022.103661
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author Tartaglia, Eleonora
Bordoni, Veronica
Oliva, Alessandra
Vergori, Alessandra
Girardi, Enrico
Antinori, Andrea
Agrati, Chiara
Liuzzi, Giuseppina
author_facet Tartaglia, Eleonora
Bordoni, Veronica
Oliva, Alessandra
Vergori, Alessandra
Girardi, Enrico
Antinori, Andrea
Agrati, Chiara
Liuzzi, Giuseppina
author_sort Tartaglia, Eleonora
collection PubMed
description T helper (Th) cell subsets play distinct and important roles during pregnancy. This work was focused on investigating the Th and cytokine profile in pregnant women recovered from COVID-19. To this aim, the frequency of Th1, Th2, Th17 subsets and the level of associated cytokines were analysed in pregnant women recovered from COVID-19 and in matched non-pregnant women. Principal component analysis highlighted a significant impact of pregnancy on Th profile with an increase of ex-Th17 subset and a parallel decrease of Th1 population. These modulations may participate in both preserving the pregnancy and reducing the risk of severe infection.
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spelling pubmed-92584272022-07-07 T helper profile in pregnant women recovered from COVID-19 Tartaglia, Eleonora Bordoni, Veronica Oliva, Alessandra Vergori, Alessandra Girardi, Enrico Antinori, Andrea Agrati, Chiara Liuzzi, Giuseppina J Reprod Immunol Short Communication T helper (Th) cell subsets play distinct and important roles during pregnancy. This work was focused on investigating the Th and cytokine profile in pregnant women recovered from COVID-19. To this aim, the frequency of Th1, Th2, Th17 subsets and the level of associated cytokines were analysed in pregnant women recovered from COVID-19 and in matched non-pregnant women. Principal component analysis highlighted a significant impact of pregnancy on Th profile with an increase of ex-Th17 subset and a parallel decrease of Th1 population. These modulations may participate in both preserving the pregnancy and reducing the risk of severe infection. The Authors. Published by Elsevier B.V. 2022-09 2022-07-06 /pmc/articles/PMC9258427/ /pubmed/35839525 http://dx.doi.org/10.1016/j.jri.2022.103661 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Tartaglia, Eleonora
Bordoni, Veronica
Oliva, Alessandra
Vergori, Alessandra
Girardi, Enrico
Antinori, Andrea
Agrati, Chiara
Liuzzi, Giuseppina
T helper profile in pregnant women recovered from COVID-19
title T helper profile in pregnant women recovered from COVID-19
title_full T helper profile in pregnant women recovered from COVID-19
title_fullStr T helper profile in pregnant women recovered from COVID-19
title_full_unstemmed T helper profile in pregnant women recovered from COVID-19
title_short T helper profile in pregnant women recovered from COVID-19
title_sort t helper profile in pregnant women recovered from covid-19
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258427/
https://www.ncbi.nlm.nih.gov/pubmed/35839525
http://dx.doi.org/10.1016/j.jri.2022.103661
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