Cargando…

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respectively. Participants prescribed LEF between 1 Janua...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakafero, Georgina, Grainge, Matthew J, Card, Tim, Taal, Maarten W, Aithal, Guruprasad P, Zhang, Weiya, Doherty, Michael, Fox, Christopher P, Mallen, Christian D, Abhishek, Abhishek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Clinical Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258529/ https://www.ncbi.nlm.nih.gov/pubmed/34718430 http://dx.doi.org/10.1093/rheumatology/keab790

Ejemplares similares

Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum
por: Nakafero, Georgina, et al.
Publicado: (2022)

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?
por: Nakafero, Georgina, et al.
Publicado: (2021)

Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink
por: Abhishek, Abhishek, et al.
Publicado: (2018)

Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink
por: Nakafero, Georgina, et al.
Publicado: (2019)

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink
por: Nakafero, Georgina, et al.
Publicado: (2019)

Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK
por: Nakafero, Georgina, et al.
Publicado: (2023)

Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation
por: Nakafero, Georgina, et al.
Publicado: (2023)

Data resource profile: Clinical Practice Research Datalink (CPRD) Aurum
por: Wolf, Achim, et al.
Publicado: (2019)

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study
por: Nakafero, Georgina, et al.
Publicado: (2018)

Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease-modifying anti-rheumatic drugs
por: Nakafero, Georgina, et al.
Publicado: (2020)

β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score–matched cohort study
por: Nakafero, Georgina, et al.
Publicado: (2021)

Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum
por: Persson, Rebecca, et al.
Publicado: (2021)

Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis
por: Nakafero, Georgina, et al.
Publicado: (2022)

Mapping the risk of infections in patients with multiple sclerosis: A multi-database study in the United Kingdom Clinical Practice Research Datalink GOLD and Aurum
por: Leung, Melissa WY, et al.
Publicado: (2022)

Presence of Codes for Indication for Use in Clinical Practice Research Datalink Aurum: An Assessment of Benign Prostatic Hyperplasia Treatments
por: Persson, Rebecca, et al.
Publicado: (2022)

Aurum in Sarcocele
Publicado: (1895)

The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink
por: Royle, Jeremy G., et al.
Publicado: (2018)

Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment
por: Abhishek, Abhishek, et al.
Publicado: (2022)

Implication of nurse intervention on engagement with urate-lowering drugs: A qualitative study of participants in a RCT of nurse led care
por: Latif, Zahira P., et al.
Publicado: (2019)

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink
por: Pearce, Fiona A, et al.
Publicado: (2018)

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink
por: Pearce, Fiona A, et al.
Publicado: (2018)

Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study
por: Kuo, Chang-Fu, et al.
Publicado: (2015)

Comorbidities in patients with gout prior to and following diagnosis: case-control study
por: Kuo, Chang-Fu, et al.
Publicado: (2016)

A retrospective study of risk factors, causative micro-organisms and healthcare resources consumption associated with prosthetic joint infections (PJI) using the Clinical Practice Research Datalink (CPRD) Aurum database
por: Perni, Stefano, et al.
Publicado: (2023)

Nasal Polypi Cured with One Dose of Aurum-M,(50m)
por: Hayes, J. R.
Publicado: (1892)

The antecedents of biliary cancer: a primary care case–control study in the United Kingdom
por: Grainge, M J, et al.
Publicado: (2009)

The appliances and prospects of aurum nanomaterials in biodiagnostics, imaging, drug delivery and combination therapy
por: Yang, Dan, et al.
Publicado: (2019)

Enzymatic degradation of granular potato starch by Microbacterium aurum strain B8.A
por: Sarian, Fean D., et al.
Publicado: (2011)

Discontinuation rate of sulfasalazine, leflunomide and methotrexate due to adverse events in a real-life setting (NOR-DMARD)
por: Mielnik, Pawel, et al.
Publicado: (2023)

Comparison of antibiotic prescribing records in two UK primary care electronic health record systems: cohort study using CPRD GOLD and CPRD Aurum databases
por: Gulliford, Martin C, et al.
Publicado: (2020)

Phenotypic and genomic comparison of Mycobacterium aurum and surrogate model species to Mycobacterium tuberculosis: implications for drug discovery
por: Namouchi, Amine, et al.
Publicado: (2017)

Leflunomide-Induced Hidradenitis Suppurativa
por: Machan, Achraf, et al.
Publicado: (2020)

Chondrocalcinosis is common in the absence of knee involvement
por: Abhishek, Abhishek, et al.
Publicado: (2012)

Semiphysiologically Based Pharmacokinetic Model of Leflunomide Disposition in Rheumatoid Arthritis Patients
por: Hopkins, AM, et al.
Publicado: (2015)

Diagnostic accuracy of serum ascites albumin gradient (SAAG) in a contemporary unselected medical cohort
por: Subhani, Mohsan, et al.
Publicado: (2022)

Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD)
por: Quint, Jennifer K, et al.
Publicado: (2014)

An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study
por: Muller, Sara, et al.
Publicado: (2015)

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic
por: Fuller, Amy, et al.
Publicado: (2022)

The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study
por: Subhani, Mohsan, et al.
Publicado: (2021)

Development and validation of self-reported line drawings for assessment of knee malalignment and foot rotation: a cross-sectional comparative study
por: Ingham, Sarah L, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_rsvkq2knl0o68keqt454gengim