A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations

Somatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single histone gene. For example, described oncohistone mutations pr...

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Detalles Bibliográficos
Autores principales: Lemon, Laramie D, Kannan, Sneha, Mo, Kim Wai, Adams, Miranda, Choi, Haley G, Gulka, Alexander O D, Withers, Elise S, Nurelegne, Hasset T, Gomez, Valeria, Ambrocio, Reina E, Tumminkatti, Rhea, Lee, Richard S, Wan, Morris, Fasken, Milo B, Spangle, Jennifer M, Corbett, Anita H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258546/
https://www.ncbi.nlm.nih.gov/pubmed/35567477
http://dx.doi.org/10.1093/g3journal/jkac120

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