Disclosing azole resistance mechanisms in resistant Candida glabrata strains encoding wild-type or gain-of-function CgPDR1 alleles through comparative genomics and transcriptomics

The pathogenic yeast Candida glabrata is intrinsically resilient to azoles and rapidly acquires resistance to these antifungals, in vitro and in vivo. In most cases azole-resistant C. glabrata clinical strains encode hyperactive CgPdr1 variants, however, resistant strains encoding wild-type CgPDR1 a...

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Detalles Bibliográficos
Autores principales: Salazar, Sara B, Pinheiro, Maria Joana F, Sotti-Novais, Danielle, Soares, Ana R, Lopes, Maria M, Ferreira, Teresa, Rodrigues, Vitória, Fernandes, Fábio, Mira, Nuno P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258547/
https://www.ncbi.nlm.nih.gov/pubmed/35532173
http://dx.doi.org/10.1093/g3journal/jkac110

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