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Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche
Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in which HSC progeny (MKs) can modulate HSC adaptat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258777/ https://www.ncbi.nlm.nih.gov/pubmed/35814384 http://dx.doi.org/10.3389/fonc.2022.912060 |
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author | Zhan, Huichun Kaushansky, Kenneth |
author_facet | Zhan, Huichun Kaushansky, Kenneth |
author_sort | Zhan, Huichun |
collection | PubMed |
description | Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in which HSC progeny (MKs) can modulate HSC adaptation to hematopoietic demands during both steady-state and stress hematopoiesis. MKs are often located adjacent to marrow sinusoids. Considering that most HSCs reside close to a marrow vascular sinusoid, as do MKs, the interactions between MKs and vascular endothelial cells are positioned to play important roles in modulating HSC function, and by extrapolation, might be dysregulated in various disease states. In this review, we discuss the interactions between MKs and the vascular niche in both normal and neoplastic hematopoiesis. |
format | Online Article Text |
id | pubmed-9258777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92587772022-07-07 Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche Zhan, Huichun Kaushansky, Kenneth Front Oncol Oncology Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in which HSC progeny (MKs) can modulate HSC adaptation to hematopoietic demands during both steady-state and stress hematopoiesis. MKs are often located adjacent to marrow sinusoids. Considering that most HSCs reside close to a marrow vascular sinusoid, as do MKs, the interactions between MKs and vascular endothelial cells are positioned to play important roles in modulating HSC function, and by extrapolation, might be dysregulated in various disease states. In this review, we discuss the interactions between MKs and the vascular niche in both normal and neoplastic hematopoiesis. Frontiers Media S.A. 2022-06-22 /pmc/articles/PMC9258777/ /pubmed/35814384 http://dx.doi.org/10.3389/fonc.2022.912060 Text en Copyright © 2022 Zhan and Kaushansky https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhan, Huichun Kaushansky, Kenneth Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche |
title | Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche |
title_full | Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche |
title_fullStr | Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche |
title_full_unstemmed | Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche |
title_short | Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche |
title_sort | megakaryocytes as the regulator of the hematopoietic vascular niche |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258777/ https://www.ncbi.nlm.nih.gov/pubmed/35814384 http://dx.doi.org/10.3389/fonc.2022.912060 |
work_keys_str_mv | AT zhanhuichun megakaryocytesastheregulatorofthehematopoieticvascularniche AT kaushanskykenneth megakaryocytesastheregulatorofthehematopoieticvascularniche |