Trans-splicing facilitated by RNA pairing greatly expands sDscam isoform diversity but not homophilic binding specificity

The Down syndrome cell adhesion molecule 1 (Dscam1) gene can generate tens of thousands of isoforms via alternative splicing, which is essential for nervous and immune functions. Chelicerates generate approximately 50 to 100 shortened Dscam (sDscam) isoforms by alternative promoters, similar to mamm...

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Detalles Bibliográficos
Autores principales: Hou, Shouqing, Li, Guo, Xu, Bingbing, Dong, Haiyang, Zhang, Shixin, Fu, Ying, Shi, Jilong, Li, Lei, Fu, Jiayan, Shi, Feng, Meng, Yijun, Jin, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258826/
https://www.ncbi.nlm.nih.gov/pubmed/35857463
http://dx.doi.org/10.1126/sciadv.abn9458

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