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Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor

With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established...

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Detalles Bibliográficos
Autores principales: Zhang, Jared R, Kueht, Michael, Lea, A Scott, Stevenson, Heather L, Gosnell, Joseph, Ren, Ping, Nielsen, Marisa C, Miller, Aaron, Mujtaba, Muhammad, Fair, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258928/
https://www.ncbi.nlm.nih.gov/pubmed/35813455
http://dx.doi.org/10.1093/jscr/rjac314
Descripción
Sumario:With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation.